Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-883-3 | CAS number: 3648-18-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
48 hour EC50 > water solubility of dioctyltin oxide, OECD 202, EU Method C.2, Hooftman & de Wolf (2004b).
48 hour EC50 > water solubility of dioctyltin oxide, OECD 202, Rufli (1988a).
48 hour EC50 (lauric acid) = 5.7 mg/L, HERA Human & Environmental Risk Assessment (2003).
Key value for chemical safety assessment
Additional information
Since no data are available on the substance itself information has been read across to the products of its hydrolysis, dioctyltin oxide and lauric acid.
The acute toxicity of dioctyltin oxide, to the fresh-water crustacean Daphnia magna, was determined in two studies, Hooftman & de Wolf (2004) and Rufli (1998). In the first study, Hooftman & de Wolf (2004), due to the insolubility of the test material, Daphnids were exposed t the test material as a water soluble fraction in a limit test. Under the conditions of the test, the 48 h EC50 of the test material was found to be greater than the water solubility of the test material. In the second report by Rufli (1988), Daphnids were only exposed for 24 hours at a range of concentrations up to a 100 % saturated solution. Similarly, no toxicity was observed in any of the Daphnia, and the EC50 was expected to be greater than the water solubility of the test material.
Both studies were performed to standardised guidelines and Hooftman & de Wolf (2004) was also conducted under GLP conditions, accordingly they have both been assigned a reliability score of 2 in accordance with Klimisch (1997).
Information on the acute toxicity of lauric acid, to the fresh-water crustacean Daphnia magna, is available in the Human & Environmental Risk Assessment (2003) report on ingredients of European household cleaning products. The report contains three 48 hour EC50 values which are all taken from secondary references. The three values were reported as 2 mg/L, 5.4 mg/L and 16.9 mg/L, respectively. The geometric mean of the available data was determined to be 5.7 mg/L. No information is provided on materials and methods, and thus the study was assigned a reliability score of 4 I line with Klimisch (1997).
Given the available data on the hydrolysis products of the substance to be registered, the EC50 can be expected to be greater than the water solubility of the test material.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
