Registration Dossier
Registration Dossier
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EC number: 222-883-3 | CAS number: 3648-18-8
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
96 hour LC50 (dioctyltin oxide) > water solubility, OECD 203, EU Method C.1, Hooftman & de Wolf (2004a).
96 hour LC50 (lauric acid) = 23 mg/L, HERA Human & Environmental Risk Assessment (2003).
Key value for chemical safety assessment
Additional information
Since no data are available on the substance itself information has been read across to the products of its hydrolysis, dioctyltin oxide and lauric acid.
The acute toxicity of dioctyltin oxide to Brachydanio rerio (zebra fish) was determined in a semi-static test conducted in accordance with standardised guidelines and under GLP conditions. Due to the insolubility of the test material the study was performed with a water soluble fraction as a limit test. Under the conditions of the study, the 96 h LC50 of the test material was found to be greater than the water solubility of the test material. The study was assigned a reliability score of 2 in accordance with the principles for assessing data quality as defined by Klimisch (1997).
Information on the acute toxicity of lauric acid to fresh-water fish is available in the Human & Environmental Risk Assessment (2003) report on ingredients of European household cleaning products. Two LC50 values were reported, 63.3 mg/L in Lepomis macrochirus and 8.6 mg/L in an unreported species. The geometric mean of the available data was determined to be 23mg/L. No information is provided on materials and methods. Accordingly this report was assigned a reliability score of 4 in line with Klimisch (1997).
Given the available data on the hydrolysis products of the substance to be registered, the LC50 can be expected to be greater than the water solubility of the test material.
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