Registration Dossier
Registration Dossier
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EC number: 212-472-7 | CAS number: 821-06-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short study summary
Data source
Reference
- Reference Type:
- other: Material Safety Data Sheet
- Title:
- Material Safety Data Sheet
- Author:
- Chemada Fine Chemicals Ltd., Israel
- Year:
- 2 009
- Bibliographic source:
- Chemada Fine Chemicals Ltd. 22/03/2009 Material Safety Data Sheet CAS number 821-06-7
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- Principles of method if other than guideline:
- No data
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- (E)-1,4-dibromobut-2-ene
- EC Number:
- 212-472-7
- EC Name:
- (E)-1,4-dibromobut-2-ene
- Cas Number:
- 821-06-7
- Molecular formula:
- C4 H6 Br2
- IUPAC Name:
- 1,4-dibromobut-2-ene
- Details on test material:
- - Analytical purity: 98%
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- other: CBA/Ca
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 0
0.25
0.5
1.0 - No. of animals per dose:
- 4 animals per dose
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
- Positive control results:
- No data
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: see Remark
- Remarks:
- Concentration (%v/v) in aceton/olive oil 1:4 Stimulation index 0.25 5.08 0.5 5.27 1 6.30
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: No data
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Conclusions:
- According to the described method the test substance trans-1,4 -Dibromo-2 -butene is classified as sensitiser following EU ( R43: May cause sensitisation by skin contact) and GHS (Skin Sens. 1) requirements.
- Executive summary:
According to the described method the test substance trans-1,4 -Dibromo-2 -butene is classified as sensitiser following EU (R43: May cause sensitisation by skin contact) and GHS (Skin Sens. 1) requirements.
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