Iodomethane

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

29 July 2010 to 05 August 2010

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

1.57

Temp.:

20 °C

pH:

>= 5.45 - <= 6.03

Details on results:

- The recovery of the QC sample analysed along with the n-octanol-saturated aqueous phases was 96.4 %. The stock solution in n-octanol showed a concentration of 1172 mg a.i./L, which is 119 % of the expected value.
- The recovery of the QC samples (in n-octanol) analysed along with the water-saturated noctanol phase was 130 %. This high values most likely due to an error during the preparation
of the sample. The QC prepared for the water samples and the measurement of the stock solution confirmed the validity of the analytical method used.
- The concentration of the test material found in the aqueous phase was between 28.1 and 31.1 mg a.i./L. The concentration in the n-octanol phase ranged from 1021 to 1285 mg a.i./L. The
calculated mean log Kow is thus 1.57. The log Kow results were within the accepted range of ± 0.3 units. The measured pH ranged from 5.45 to 6.03.
- The log Kow value obtained from the literature of 1.5 is similar to the log Kow found during this study.

Conclusions:

Under the conditions of this study, the log Kow of the test material was 1.57.

Executive summary:

The partition coefficient of the test material was investigated in accordance with the standardised guideline OECD 107, under GLP conditions using the shake-flask method with HPLC.

The concentration of the test material found in the aqueous phase was between 28.1 and 31.1 mg a.i./L. The concentration in the n-octanol phase ranged from 1021 to 1285 mg a.i./L. The calculated mean log Kow is thus 1.57. The log Kow results were within the accepted range of ± 0.3 units. The measured pH ranged from 5.45 to 6.03. The log Kow value obtained from the literature of 1.5 is similar to the log Kow found during this study.

Under the conditions of this study, the log Kow of the test material was 1.57.

Description of key information

Under the conditions of this study, the log Kow of the test material was 1.57.

Key value for chemical safety assessment

Log Kow (Log Pow):

1.57

at the temperature of:

20 °C

Additional information

The partition coefficient of the test material was investigated in accordance with the standardised guideline OECD 107, under GLP conditions using the shake-flask method with HPLC. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

The concentration of the test material found in the aqueous phase was between 28.1 and 31.1 mg a.i./L. The concentration in the n-octanol phase ranged from 1021 to 1285 mg a.i./L. The calculated mean log Kow is thus 1.57. The log Kow results were within the accepted range of ± 0.3 units. The measured pH ranged from 5.45 to 6.03. The log Kow value obtained from the literature of 1.5 is similar to the log Kow found during this study.

Under the conditions of this study, the log Kow of the test material was 1.57.