Registration Dossier

Environmental fate & pathways

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Additional information

The experimentally derived log Pow of amides, C12-18 (even numbered) and C18-unsatd., N,N-bis(hydroxyethyl) is 4.2 at 25°C. A BCF calculation using the weighted mean yielded a value of 58 L/kg w/w, suggesting low bioaccumulation potential. This assumption is strongly supported by available toxicokinetics data. According to Section 5.1.3,  amides, C12-18 (even numbered) and C18-unsatd., N,N-bis(hydroxyethyl) is not expected to significantly bioaccumulate because of its rapid and effective metabolism by P450 enzymes to innocuous polar metabolites which are rapidly excreted (primarily) in urine.