Benzophenone-3,3':4,4'-tetracarboxylic dianhydride

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Precedes establishment of guideline and GLP. Documentation is limited.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1963

Report date:

1963

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

yes

Remarks:

; intact and abraded skin, 4 animals rather than 5 per dose group, evaluation scale for dermal toxicity includes erythema, edema, atonia, desquamation, coriaceous injury and fissuring.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Benzophenone-3,3':4,4'-tetracarboxylic dianhydride

EC Number:

219-348-1

EC Name:

Benzophenone-3,3':4,4'-tetracarboxylic dianhydride

Cas Number:

2421-28-5

Molecular formula:

C17H6O7

IUPAC Name:

5-(1,3-dioxo-1,3-dihydro-2-benzofuran-5-carbonyl)-1,3-dihydro-2-benzofuran-1,3-dione

Constituent 2

Reference substance name:

291-348-1

IUPAC Name:

291-348-1

Test material form:

solid: crystalline

Test animals

Species:

rabbit

Strain:

other: albino, strain not given

Sex:

not specified

Details on test animals or test system and environmental conditions:

Individually housed in metal cages suspended above the droppings. Food and water were available ad libitum. At the end of the experiment, all rabbits were weighed, sacrificed by air embolization and necropsied. Rabbits that succumbed were necropsied also.

Administration / exposure

Type of coverage:

occlusive

Vehicle:

ethanol

Remarks:

25%

Details on dermal exposure:

TEST SITE
- Area of exposure: 5 inches by 5 inches
- Type of wrap if used: The test material, as a paste, was distributed evenly over a piece of rubber dental dam, secured with adhesive tape and held in place with an elastic bandage.

REMOVAL OF TEST SUBSTANCE
- Washing (if done): Material was scraped from the abdomen skin; no washing was noted.
- Time after start of exposure:

TEST MATERIAL
- For solids, paste formed: yes; A semi-liquid mass was made with the powdered test material in 25% ethanol.

VEHICLE
- Concentration (if solution): 25% ethanol

Duration of exposure:

24 hours

Doses:

50, 200, 794, 3160 mg/kg

No. of animals per sex per dose:

4

Control animals:

no

Details on study design:

Skin was clipped with an electric clipper. The skin of 2 of the 4 rabbits in each group was abraded with a scalpel blade. Observation period: 14 days after removal of patch

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD0

Effect level:

> 3 160 mg/kg bw

Based on:

test mat.

Remarks on result:

other: no deaths

Mortality:

no deaths

Clinical signs:

other: no signs of irritation or systemic toxicity

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Remarks:

Migrated information

Conclusions:

1,3-Isobenzofurandione, 5,5'-carbonylbis- (BTDA) was studied in albino rabbits in an acute dermal lethality test similar to an OECD 402 protocol. No animals died during the 14-day test at the highest dose of 3160 mg/kg body weight.