Registration Dossier
Registration Dossier
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EC number: 233-713-2 | CAS number: 10326-41-7
Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: long-term
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Description of key information
According to REACH Annex X, point 9.5.1, long-term toxicity testing for sediment organisms shall be proposed if the chemical safety assessment according to Annex I indicates the need to investigate further the effects on sediment organisms. Lactic acid is readily biodegradable (see 5.2.1) and is a ubiquitous and essential molecule of life. Furthermore, it will not adsorb to sediment (see 5.4.1). Therefore, lack of hazards for sediment organisms is concluded following the principles of the equilibrium-partitioning method.
Key value for chemical safety assessment
Additional information
The ecotoxicity of L-lactic acid is primarily related to its effects on pH. This is clearly evidenced by the large discrepancy between the toxicity to aquatic organisms of lactic acid and salts like sodium lactate. D- and L-lactic acid have identical pKa values. Furthermore, both L- and D-lactic acid are ubiquitous and essential molecules in all biological systems, and organisms are continuously exposed to significant internal and external background concentrations of L- as well as D-lactic acid. As such information on the ecotoxicity of L-lactic acid is fully valid for D-lactic acid.
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