Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

The ability of CS-1246 to induce dermal sensitization was examined in a Guinea Pig Maximization Test (Kreuzmann, J.J., 1989). Based on results of the induction/challenge CS-1246 was determined to be a dermal sensitizer in guinea pigs.



Kreuzmann, J.J. (1989) Guinea Pig Maximization Test (Magnusson and Kligman Method). Hill Top Biolabs. The Dow Chemical Company Report No: DR-0365-7725-005. GLP, Unpublished

Migrated from Short description of key information:
Based on a positive result in the guinea pig maximization study, the substance is expected to be a dermal sensitizer.

Justification for classification or non-classification

The substance is classified as Xi R43 (May cause sensitization by skin contact) according to DSD and as as a Skin sensitizer Cat.1; H317 (May cause an allergic reaction) according to CLP.