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EC number: -
CAS number: -
The study has been performed according to OECD 203 and EU method C.1 in a GLP certified testing facility.The main study was performed as a limit test in the range of water solubility. Due to the low water solubility of the test substance the water-accommodated fraction was prepared for the test using a loading rate of 10 mg/L. The treatment showed no mortality.The following results for the test item 400160 could be determined:96h NOELR ≥ 10 mg/L96h LL50 > 10 mg/L
was performed in order to evaluate the toxic potential of 400160 towards
freshwater fish, using the species Danio rerio Hamilton Buchanan. A
short-term study in a static test design was performed according to
guidelines OECD 203 and EU C.1. All validity criteria were met.
non-GLP pre-test with filtrated test solution using a loading rate of
100 mg/L no mortality was observed over a period of 96 h. Due to
filtration difficulties unfiltrated test solution containing a loading
rate of 10 mg/L was used in the main study.
Due to the
low water solubility of 400160 (9.38 ± 1.42 mg/L at 20 ± 0.3°C) the
water-accommodated fraction was prepared for the test. The study was
performed as limit test with a loading rate of 10 mg/L. The measured
DOC-values of the blank controls and the treatment lay below the limit
of quantification due to the very low solubility in medium. Solubility
in deionised water is not comparable with solubility in dilution water.
As no quantification of the test item in the treatments was possible,
the biological results were based on the nominal concentration.
mortalities up to a nominal concentration of 10 mg/L were observed under
the conditions tested. Therefore, the LL50 is significantly higher than
observations were made which might cause doubts concerning the validity
of the study outcome.
of the test is considered valid.
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