Registration Dossier
Registration Dossier
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EC number: 608-544-6 | CAS number: 3082-64-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Currently, there are no studies available regarding skin sensitization. Nevertheless, there is a reliable study existing, which may serve as read across for this endpoint: (S)-1 -Phenyl-propylamine (CAS 3789-59-1).
The substance (S)-1-phenylpropylamine (CAS 3789-59-1, read across) was tested for its sensitizing effect on the skin of the local lymph node assay based on the OECD method 429 (skin sensitization). The results of this assay indicate that the test article, at the concentrations tested, did not induce a hypersensitivity response according to the criteria used for a positive response. [Calvert Preclinical Services, 2001]
Migrated from Short description of key information:
(S)-1 -Phenyl-propylamine (CAS 3789-59-1, read across) was not sensitizing in the LLNA (OECD 429). [Calvert Preclinical Services, 2001]
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
- Migrated from Short description of key information:
Currently, there is no information available.
Justification for classification or non-classification
Based on the available data for (S)-1 -Phenyl-propylamine (CAS 3789-59-1, read across), (R)-1-Phenyl-propylamine is not subject to C&L according to Regulation 1272/2008/EC and Directive 67/548/EEC. There is no information given, that (R)-1-Phenyl-propylamine is a sensitizer of the respiratory tract.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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