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EC number: 449-400-0
CAS number: -
The performance of a hydrolysis as a
function of pH test is scientifically not justified as the test item is
practically insoluble in water.
Biodegradation in water: screening tests
A study was performed to determine the
potential for ready biodegradation of the test item by the carbon
dioxide (CO2) evolution method following OECD 301B, adopted in 1992. The
CO2 released upon biodegradation of the test item and the reference
substance sodium benzoate was measured. Two blank controls (containing
only inoculum) and a toxicity control (containing inoculum, reference
and test substances) were established to account for background CO2
production and toxicity of the test item, respectively. All validation
criteria were fulfilled. The sodium benzoate controls had degraded > 60
% at day 8. Based on the CO2 analysis, there was no biodegradation
observed for the test item within the 28 days. The degradation of the
test item was therefore less than the minimal guideline demand of 60
%.Therefore the test item is considered to be not readily biodegradable.
Biodegradation in water and sediment:
Biodegradation in soil
Direct and indirect exposure of the test
item to water, sediment and soil is unlikely. The test substance is
practically insoluble in water. In addition, low exposure is guaranteed,
as no sludge application from STP on soil will be done and aerial
deposition is negligible. Thus, simulation testing for biodegradation in
water, sediment and soil was considered not scientifically justified.
The bioaccumulation factor for the main
component (dimer) of the test substance was estimated to be 1112 L/kg
wwt using the software EPIWIN v4.11, BCFBAF v3.01.
Transport and Distribution
The adsorption/ desorption coefficient Koc
of the test item was assessed using an HPLC method according to OECD
121, adopted in 2001. 15 µL of the test item solution (4.3 mg/L mobile
phase) were injected onto the column. The retention time of the test
item was determined in duplicate and the capacity factor k was
calculated. The assay was performed with pH 7.2 at 35°C. 6 reference
compounds were included according to the guideline. The calculated log
Koc was estimated to be 6.5 at pH 7.2 (PCKOCWIN). This corresponds to a
Koc = 3.23 x 10E06.The experimentally derived logKoc which was deduced
from the capacity factor k' using a calibration plot of log k' versus
log Koc of the reference compounds, was6.49 with pH 7.2 at 35°C. This
corresponds to a Koc = 3.1 x 10E06. Based on this result it is estimated
that the test item is not water soluble and it may adsorb to organic
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