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Diss Factsheets

Physical & Chemical properties

Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 21 May 2012 to 24 August 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
2012-12-15
Type of method:
other: Differential Scanning Calorimetry method
Key result
Melting / freezing pt.:
> 50 - < 55 °C
Atm. press.:
> 98 - < 98.3 kPa

Five assays were performed during the test, the temperature values obtained for the melting point varied between 54.7 and 61.5 °C. The mean value for the melting point is explained as the mean of at least two assays for which the melting point value are in the range of the estimated accuracy of the method: ± 0.5 °C up to 326.9 °C and ± 2.0 °C above 326.9 °C.

The assays No. 2 and 3 were taken into account for the melting point.

Assay

Atmospheric pressure (kPa)

Crucible used

Mass of test item

Programmation

Temperature of melting (°C)

1

98.3

Aluminium, 120 μL, with pierced lid

5.38 mg

Isotherm at 25 °C for 2 min

Heating phase from 25 to 500 °C at 20 °C/min

Cooling phase from 500 to 25 °C at 50 °C/min

Isotherm at 25 °C for 10 min

56.7

2

98.3

11.84 mg

Isotherm at 25 °Cfor 2 min

Heating phase from 25 to 400 °C at 10 °C/min

Cooling phase from 400 to 25 °C at 50 °C/min

Isotherm at 25 °C for 10 min

54.7

3

98.0

9.25

Isotherm at 25 °C for 2 min

Heating phase from 0 to 400 °C at 10 °C/min

Cooling phase from 400 to 25 °C at 50 °C/min

Isotherm at 25 °C for 10 min

55.2

4

98.0

10.10

Isotherm at 25 °C for 10 min

Heating phase from 0 to 400 °C at 10 °C/min

Cooling phase from 400 to 25 °C at 50 °C/min

Isotherm at 25 °C for 10 min

58.8

5

98.0

8.08

Isotherm at 25 °C for 10 min

Heating phase from 25 to 400 °C at 10 °C/min

Cooling phase from 400 to 25 °C at 50 °C/min

Isotherm at 25 °C for 10 min

61.5

The mean melting point of the test item was 55.0 ± 0.5°C

Conclusions:
The mean melting point of the test item was 55.0 ± 0.5°C
Executive summary:

The melting point of the REACh substance (2-Hydroxy-3-sulphopropyl) dimethyl[3-[(1-oxododecyl) amino]propyl]ammonium hydroxide (EC 242-893-1) was investigated in a GLP-compliant study performed in accordance with OECD Guideline 102 (Melting point / Melting Range) and EU Method A.1 (Melting / Freezing Temperature). The mean melting point of the test item was 55.0 ± 0.5 °C.

Description of key information

The melting point of the REACh substance (2-Hydroxy-3-sulphopropyl) dimethyl[3-[(1-oxododecyl) amino]propyl]ammonium hydroxide (EC 242-893-1) was investigated in a GLP-compliant study (Ferron, 2012) performed in accordance with OECD Guideline 102 (Melting point / Melting Range) and EU Method A.1 (Melting / Freezing Temperature). The mean melting point of the test item was 55.0 ± 0.5 °C.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
55 °C

Additional information

The melting point of the substance EC 242-893-1 was investigated in a GLP-compliant study (Ferron, 2012) performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and was selected as key study for the endpoint.