Registration Dossier
Registration Dossier
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EC number: 404-360-3 | CAS number: 119313-12-1 CG 25-369; IRGACURE 369; TK 11-319
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Data waiving:
- exposure considerations
- Justification for data waiving:
- other:
Data source
Materials and methods
Test material
- Reference substance name:
- 2-benzyl-2-dimethylamino-4'-morpholinobutyrophenone
- EC Number:
- 404-360-3
- EC Name:
- 2-benzyl-2-dimethylamino-4'-morpholinobutyrophenone
- Cas Number:
- 119313-12-1
- Molecular formula:
- C23H30N2O2
- IUPAC Name:
- 2-benzyl-2-(dimethylamino)-1-[4-(morpholin-4-yl)phenyl]butan-1-one
Constituent 1
Results and discussion
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- In view of no data being presented in the 28 day oral toxicity study that indicated effects to the reproductive organs and there being no similarity with known reproductive toxcins, it is not considered justified to perform a new animal test.
- Executive summary:
There is predicted to be low exposure to workers under controlled workplace conditions and no exposure to the general public. EUSES modelling with ConsExpo suggests a low risk of accumulation in food and drinking water.
The absence of relevant systemic effects in the 28 day oral study and the low exposure would suggest it is inappropariate to perform further animal studies to meet this end point. If the tonnage exceeds 100 t per annum or if use types change that could lead to increased human exposure, testing may be necessary.
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