Registration Dossier
Registration Dossier
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EC number: 200-311-3 | CAS number: 57-09-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
In the key study, the acute toxicity to zebrafish (Danio rerio) of cetrimonium bromide was determined to be 0.2 mg/L representing LC50 (96h).
In other studies, LC50 (96h) values were obtained for other freshwater fish species: Japanese rice fish (Oryzia latipes) and fathead minnow (Pimephales promelas) with LC50 values varying between 0.1-0.28 mg/l. In addition, a value for LC50 (24h) was established to 0.6 mg/l for rainbow trout (Onchorhynchus mykiss).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.2 mg/L
Additional information
Three different LC50(96h) values have been identified for cetrimonium bromide on acute toxicity to fish. All LC50(96h) values are in the same range and varied between 0.1 and 0.28 mg/l. The LC50(96h) determined in the key study performed according to OECD Guideline 203 and according to GLP is chosen for the CSA based on the well-documented study. One study identified a correlation between toxicity of alkyl trimethylammonium compounds and the presence of organic matter. The presence of organic matter seems to reduce the toxicity of alkyl trimethylammonium compounds in a dose-dependent manner. LC50 values obtained in the laboratory without the presence of organic matter, is therefore likely to overestimate the actual toxicity under natural conditions.
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