Registration Dossier
Registration Dossier
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EC number: 200-431-6 | CAS number: 59-50-7
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Classification of chlorocresol for effects in the environment
Several major guideline – estimation values (Klimisch 2) are available for Chlorocresol, indicates substantial toxic effect in all the 3 key trophic levels (fish, invertebrate and algae). Among the values lower values which lead to the classification of the substance the value which have been considered for further calculation (invertebrate) is EC50 = 1.5 mg/L.
In determining the classification appropriate to chlorocresol, it is necessary to consider all available evidence concerning its persistence, potential to accumulate and predicted or observed environmental fate and behaviour that may present a long-term and/or delayed danger to the structure and/or functioning of aquatic ecosystems. These points are considered below.
Persistence
Reliable studies are available to demonstrate that chlorocresol is non persistent in nature and so is considered to have rapid biodegradation in the environment. In other words chlorocresol degradation may therefore be expected to be fast. Thus it can be inferred that chlorocresol is non persistent in character.
Chlorocresol is non persistent and so do not satisfy the criteria for classification as persistent (P).
Potential to accumulate
Predicted and measured log Kow values for chlorocresol is less than 4 (Log Kow = 0.477). The potential for chlorocresol to bioaccumulate in the tissues of organisms that inhabit aquatic or terrestrial matrices is negligible as the BCF factor for the substance is less than 1000.
The calculated BCF of chlorocresol is 11 dimensionless and below the threshold of 2000.
Chlorocresol does not satisfy the criterion for classification as bioaccumulative (B).
The toxicity values of fish, invertebrates and algae are LC50 = 6.71 mg/L, EC50 = 1.5 mg/L are EC10 = 2.5 mg/L, respectively. The toxicity values of all the trophic levels fall in the criteria for classification (CLP regulation). But the BCF value of chlorocresol reported was not >= 2000 as well as the substance was found to be rapidly degradable. Thus according to CLP criteria of aquatic classification it is concluded that the substance chlorocresol is not toxic to aquatic environment.However, since this chemical has a harmonized classification as "Aquatic acute 1 " category, for the pupose of chemical safety assessment, this classification shall be considered.
So, chlorocresol satisfies the environmental effects criterion for classification as toxic (T).
Thus it can be inferred that chlorocresol not P & B (including vPvB) substance, but will qualify as T. But as per Annex XIII of REACH regulation the overall inference for the substance is not PBT
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