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EC number: 618-126-5
CAS number: 88196-70-7
(S)-1-(3-Methoxyphenyl)ethylamine was tested for its sensitizing effect
on the skin of the guinea pig in the Maximization Test based on the
method of Magnusson and Kligman. The test-substance concentrations for
the main test were selected based on the results of the pretests. The
intradermal induction was performed with a 0.5% test-substance
preparation in peanut oil Ph.Eur. 5.5 or 0.5% test substance preparation
in Freund’s complete adjuvant / 0.9% aqueous NaCl-solution (1 : 1) and
the epicutaneous induction with a 1% test-substance preparation in
peanut oil Ph.Eur. 5.5. For the challenge, a 0.5% test-substance
preparation in peanut oil Ph.Eur. 5.5 was chosen. The study was
performed using 1 control group and 1 test group. The intradermal
induction was performed on day 0 and the epicutaneous induction on day
7. A challenge was carried out 14 days after the epicutaneous induction.
The intradermal induction caused intense erythema and swelling at the
injection sites of the test-substance preparations in all test group
animals. After the epicutaneous induction, incrustation, partially open
(caused by the intradermal induction) could be observed in addition to
moderate and confluent erythema and swelling in all test group animals.
After the challenge discrete or patchy to moderate and confluent
erythema, swelling and scaling were observed in the test group animals.
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