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Attuali
Here you can find the substances and hazard endpoints for which ECHA is currently inviting third parties to submit scientifically valid information and studies.
Please also note the following:
The link(s) under 'View dossier' to the ECHA CHEM Database allows easy access to the dossier(s) containing further details on the testing proposed including the test method (e.g. if a modified test method for a repeated dose toxicity study has been proposed). If the related dossier has not yet been disseminated or the substance identity is confidential, such a link cannot be given.
The Total Tonnage Band published does not necessarily reflect the registered tonnage band(s) and associated information requirement obligations. For the 'Total Tonnage Band' of the disseminated dossier, compiled data is calculated from the non-confidential quantities of a substance manufactured and/or imported by all registrants, excluding any quantity directly used as an intermediate to produce a different chemical.
In some cases, the registrant may propose testing under Annex IX and X of the REACH Regulation even if the registration tonnage band is lower than the tonnage band of the REACH Annex for which the test is proposed. Such specific testing proposals may be triggered by a concern identified from previous study results and their assessment in the chemical safety report (e.g. based on Annex I.0.5 or the second column of Annex VIII section 8.7.1). This is indicated with a note after each relevant endpoint showing that the testing proposal is based on a concern identified by the registrant.
For testing proposals on extended one-generation reproductive toxicity study (EOGRTS) third parties are invited to submit scientifically valid information and studies especially on reproductive toxicity, (developmental) immunotoxicity, (developmental) neurotoxicity and endocrine disruption (evidence on hormonal changes).
The registrant may have proposed to apply a read-across/category approach for one or more of the testing proposals based on adaptation according to Annex XI.1.5 of the REACH Regulation. This is indicated for the relevant testing proposal endpoint(s) with a note that testing is proposed for another substance than the registered substance, giving the proposed test substance name and, where available, the EC or CAS number.
| (thiodi-4,1-phenylene)-bis-(diphenylbis)(OC-6,11)hexafluoroantimonate | 680-222-8 | 89452-37-9 | 07/10/2024 | 7.6.2 Genetic toxicity in vivo | Give Comments | Details |
| 1,1,1-Tri((1,3-dioxobutoxy)-methyl)-propane | 422-630-9 | - |
07/10/2024 07/10/2024 07/10/2024 |
6.1.2 Long-term toxicity to fish 7.5.1 Repeated dose toxicity: oral 7.8.2 Developmental toxicity / teratogenicity |
Details | |
| 1,1,3,3-tetramethyldisiloxane | 221-906-4 | 3277-26-7 | 07/10/2024 | 7.8.2 Developmental toxicity / teratogenicity | Give Comments | Details |
| 3-(diethoxymethylsilyl)propylamine | 221-660-8 | 3179-76-8 |
07/10/2024 07/10/2024 |
7.5.1 Repeated dose toxicity: oral 7.8.2 Developmental toxicity / teratogenicity |
Details | |
| 3-[(phenylcarbamoyl)amino]phenyl 4-methylbenzene-1-sulfonate | 866-700-0 | 2102522-55-2 |
07/10/2024 07/10/2024 |
7.5.1 Repeated dose toxicity: oral 7.8.2 Developmental toxicity / teratogenicity |
Details | |
| 4,4'-Isopropylidenediphenol, ethoxylated | 500-082-2 | 32492-61-8 |
07/10/2024 07/10/2024 |
7.6.2 Genetic toxicity in vivo 7.8.1 Toxicity to reproduction |
Details | |
| 4,4'-Isopropylidenediphenol, ethoxylated, esters with fatty acids, coco | 500-303-2 | 115340-85-7 | 07/10/2024 | 7.6.2 Genetic toxicity in vivo | Give Comments | Details |
| Amines, C16-18 (even numbered)-alkyl , salts with phosphoric acid, mono- and di-C16-18 (even numbered) alkyl esters | 952-252-4 | - | 07/10/2024 | 5.3.1 Bioaccumulation aquatic / sediment | Give Comments | Details |
| Ascophyllum nodosum, ext. | 283-907-6 | 84775-78-0 | 07/10/2024 | 6.1.2 Long-term toxicity to fish | Give Comments | Details |
| Cyclobutanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]- | 627-199-2 | 120728-10-1 | 07/10/2024 | 7.6.2 Genetic toxicity in vivo | Give Comments | Details |
| D-gluconic acid | 208-401-4 | 526-95-4 | 07/10/2024 | 6.1.2 Long-term toxicity to fish | Give Comments | Details |
| decasodium 4,4'-bis[[4-(1S) -1,2-dicarboxyethylamino) -6-(2,5-disulfonatoanilino) -1,3,5-triazin-2-yl]amino]-2,2'-disulfonato-(E)-stilbene | 432-690-8 | 213910-67-9 | 07/10/2024 | 6.1.2 Long-term toxicity to fish | Give Comments | Details |
| dichloro(diphenyl)silane | 201-251-0 | 80-10-4 | 07/10/2024 | 6.1.2 Long-term toxicity to fish||Note: testing proposed with diphenylsilanediol (EC no. 213-427-4 CAS no. 947-42-2) | Give Comments | Details |
| Ethane-1,2-diyl palmitate | 210-826-5 | 624-03-3 | 07/10/2024 | 7.6.2 Genetic toxicity in vivo | Give Comments | Details |
| Furan-2,5-dicarboxylic acid | 221-800-8 | 3238-40-2 | 07/10/2024 | 7.8.1 Toxicity to reproduction | Give Comments | Details |
| HDI oligomers, iminooxadiazindione | 931-297-3 | - | 07/10/2024 | 7.8.1 Toxicity to reproduction||Note: testing proposed with HDI oligomers, isocyanurate (EC no. 931-274-8) | Give Comments | Details |
| Pivalic acid | 200-922-5 | 75-98-9 | 07/10/2024 | 6.1.2 Long-term toxicity to fish | Give Comments | Details |
| Polysulfides, di-tert-Bu | 273-103-3 | 68937-96-2 |
07/10/2024 07/10/2024 07/10/2024 07/10/2024 07/10/2024 |
6.1.2 Long-term toxicity to fish 7.5.1 Repeated dose toxicity: oral||Note: testing proposed with Di-tert-butyl trisulphide (EC no. 224-226-6) 7.8.1 Toxicity to reproduction 7.8.2 Developmental toxicity / teratogenicity second species 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Di-tert-butyl trisulphide (EC no. 224-226-6) first species |
Details | |
| Reaction mass of isopentyl hexadecanoate and isopentyl 8-(3-octyloxiran-2-yl)octanoate and isopentyl 8-(3-((3-pentyloxiran-2-yl)methyl)oxiran-2-yl)octanoate | 700-659-0 | - |
07/10/2024 07/10/2024 |
7.8.1 Toxicity to reproduction 7.8.2 Developmental toxicity / teratogenicity |
Details | |
| Reaction products of fatty acids, C18-unsaturated, dimers and 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bisoxirane | 701-484-2 | - | 07/10/2024 | 6.1.2 Long-term toxicity to fish | Give Comments | Details |
| Synthetic wollastonite | 952-026-5 | - | 07/10/2024 | 6.1.2 Long-term toxicity to fish | Give Comments | Details |
| α,α,α-trifluorotoluene | 202-635-0 | 98-08-8 |
07/10/2024 07/10/2024 07/10/2024 |
6.1.2 Long-term toxicity to fish 7.5.1 Repeated dose toxicity: oral 7.8.2 Developmental toxicity / teratogenicity |
Details | |