Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-278-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Remarks:
- Solubility in octanol
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008
- Version / remarks:
- Flask method based on the regulatory solubility methods
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995
- Version / remarks:
- Flask method based on the regulatory solubility methods
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- - Appearance/physical state: White solid
- Batch: A026/99 and A026/50-01
- Purity: 100% (UVCB)
- Expiry date: 01 July 2019
- Storage conditions: Room temperature, in the dark - Medium:
- n-octanol
- Solubility:
- < 0 g/L
- Test substance stable:
- not determined
- Details on results:
- On completion of the static re-equilibration period at 20°C, the saturated solution was observed to be a clear colourless solution, containing excess, undissolved test item observed as fine, irregular shaped particular matter, in suspension. This indicated that the solubility of the test item in n-octanol was less than 4.1 x 10-4 g/L of solution at 20°C.
- Conclusions:
- The solubility of the test item in n-octanol was determined to be less than 4.1 x 10-4 g/L of solution at 20°C.
- Executive summary:
An attempt was made to determine the octanol solubility of sodium 4-[(C16-18-(even numbered)-alkylamino)carbonyl]benzoate, in a GLP-compliant study following OECD guideline 105 (Envigo 2018). The study is considered relevant and reliable for use for this endpoint.
The solubility of the test item in n-octanol was determined to be less than 4.1 x 10-4 g/L of solution at 20°C. Due to the absence of a valid analytical technique to evaluate the saturated solutions generated, a solubility limit test was performed by visual assessment. On completion of the static re-equilibration period at 20°C, the saturated solution was observed to be a clear colourless solution, containing excess, undissolved test item observed as fine, irregular shaped particular matter, in suspension.
Reference
The 72 hour saturation period employed in the evaluation represented the maximum standardized time specified in the two regulatory solubility methods referenced. Due to a number of characteristics presented by this substance, it was necessary to resort to a visual assessment alone to address the solubility of the test item in n-octanol. The test item is known to be insoluble in commonly used chromatographic solvents, including tetrahydrofuran, acetic acid, chloroform, dimethyl sulfoxide, dimethylformamide, water, octane, hexane, pyridine and methanol. This insolubility prevented both the development of a suitable, substance specific method of analysis, as well as the ability to prepare standard solutions of know concentrations with which to accurately quantify the saturated solutions generated by this testing. Gravimetric analysis was considered as an alternative; however the boiling temperature of n-octanol is 195°C and the test item was identified to thermally decompose at approximately this temperature. Therefore, it was concluded that the test item thermal stability/integrity would be compromised during the significant boiling/drying time necessary to evaporate the volumes of n-octanol required to obtain a meaningful solubility limit value gravimetrically.
Description of key information
The solubility of the test item in n-octanol was determined to be less than 4.1 x 10-4 g/L of solution at 20°C. Due to the absence of a valid analytical technique to evaluate the saturated solutions generated, a solubility limit test was performed by visual assessment. On completion of the static re-equilibration period at 20°C, the saturated solution was observed to be a clear colourless solution, containing excess, undissolved test item observed as fine, irregular shaped particular matter, in suspension.
Key value for chemical safety assessment
Additional information
An attempt was made to determine the octanol solubility of sodium 4-[(C16-18-(even numbered)-alkylamino)carbonyl]benzoate, in a GLP-compliant study following OECD guideline 105 (Envigo 2018). The study is considered relevant and reliable for use for this endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.