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EC number: 943-381-7 | CAS number: 2156594-85-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The registration substance is irritating to skin and not irritating to eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-09-13 - 1994-11-01
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Scientifically well performed and well documented. Guideline study: GLP study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 4h
- Observation period:
- 21 days
- Number of animals:
- 3 rabbits
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- other: 24, 48, 72h
- Score:
- 2.9
- Max. score:
- 3
- Reversibility:
- fully reversible within: 21 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24,48, 72h
- Score:
- 1.2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 14 days
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The registration substance induced reversible irritating effects in rabbits. According to EU criteria, the registration substance should be classified as "irritating".
- Executive summary:
The registration substance was investigated for its skin irritation property according to Guideline OECD 404. Three rabbits were administered semiocclusively by the undiluted registration substance for 4 hours and the skin irritation effects were observed for up to 21 days. Erythema of scores of up to 3 and oedema of scores of up to 2 was observed within the first three days of the observation period. Two animals exhibited on observation day 14 erythema of scores of 1, which were no more present on observation day 21.
The registration substance should be classified as "irritating" according to the EU criteria.
Reference
Result:
Animal no. |
Effect |
Hour |
Days after application |
Mean score erythema (24/48/72 h) |
Mean score oedema (24/48/72 h) |
|||||
0.5 - 1 |
1 |
2 |
3 |
7 |
14 |
21 |
||||
69 |
Erythema Oedema |
3 0 |
3 2 |
3 1 |
3 1 |
2 1 |
0 0 |
|
3.0 |
1.3 |
113 |
Erythema Oedema |
2 0 |
3 2 |
3 1 |
3 1 |
1 0 |
1 0 |
0 0 |
3.0 |
1.3 |
114 |
Erythema Oedema |
2 0 |
3 2 |
3 1 |
2 0 |
1 0 |
1 0 |
0 0 |
2.7 |
1.0 |
Mean all animals |
|
|
|
|
|
|
|
|
2.9 |
1.2 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Scientifically well performed and well documented. Guideline study: GLP study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- a single application of 0.1 ml of test substance into the eye
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 3
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- of three animals at three reading time
- Time point:
- other: 24, 48, 72h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- of three animals at three reading time
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- of three animals at three reading time
- Time point:
- other: 24, 48, 72 h
- Score:
- 1.4
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of three animals at three reading time
- Time point:
- other: 24, 48, 72 h
- Score:
- 0.7
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7 days
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The registration substance induced transient conjunctivae redness and chemosis in rabbits. According to EU criteria, no classification is warranted for the registration substance.
- Executive summary:
The registration substance was investigated for its eye irritation property according to Guideline OECD 405. Three rabbits were used. The undiluted registration substance was applied into eye. Conjuctivae redness of scores up to 2 and chemosis of scores of 1 were observed within the first three days of the observation period. The observed effects were fully reversible within 7 days of observation period.
No classificaiton is warranted for the registration substance according to the EU criteria.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The registration substance was investigated for its skin irritation property according to Guideline OECD 404. Three rabbits were administered semiocclusively by the undiluted registration substance for 4 hours and the skin irritation effects were observed for up to 21 days. Erythema of scores of up to 3 and oedema of scores of up to 2 was observed within the first three days of the observation period. Two animals exhibited on observation day 14 erythema of scores of 1, which were no more present on observation day 21.
The registration substance should be classified as "irritating" according to the OECD GHS criteria.
The registration substance was investigated for its eye irritation property according to Guideline OECD 405. Three rabbits were used. The undiluted registration substance was applied into eye. Conjuctivae redness of scores up to 2 and chemosis of scores of 1 were observed within the first three days of the observation period. The observed effects were fully reversible within 7 days of observation period.
No classificaiton is warranted for the registration substance according to the OECD GHS criteria.
Justification for selection of skin irritation / corrosion endpoint:
Scientifically well performed and well documented Guideline study performed under GLP.
Justification for selection of eye irritation endpoint:
Scientifically well performed and well documented Guideline study performed under GLP.
Effects on skin irritation/corrosion: irritating
Justification for classification or non-classification
For the skin irritation/corrosion property the registration substance should be classified as Cat 2, H315.
For the eye irritation, no classification is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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