Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 811-180-2 | CAS number: 69249-22-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Administrative data
First-aid measures
Inhalation: After inhalation move to fresh air. If shortness of breath occurs, support respiration and consult a physician. Bring patient immediately to fresh air. If breathing is heavily give oxygen; if necessary respirate artificially. Call physician.
Skin Contact: Remove contaminated clothing. Rinse contaminated skin immediately with plenty of water and soap and seek medical advice.
Eye Contact: Immediately rinse eyes thoroughly with running water as long as possible (approx. 15 min). Take injured quickly to factory medical center or call an ambulance (code word: eye accident).
Ingestion: Do not induce vomiting. In case of consciousness wash mouth with water and let drink some water. Seek medical advice. Keep patient at rest. If swallowed, seek medical advice immediately and show the container or label.
Notes to Physician:
General measures to eliminate the substance and to reduce absorption: Apply general supportive and symptomatic treatment.
Fire-fighting measures
Suitable Extinguishing Media: Alcohol resistent foam, Dry sand, carbon dioxide (CO2)
Unsuitable Extinguishing Media: Water, Fire-extinguishing powder.
Dangerous Combustion Products: hydrogen bromide, nitrogen oxides, carbon oxides
Advice for firefighters:
Protective equipment for firefighters: Wear self-contained breathing apparatus and fire protective suit.
Accidental release measures
1. Personal precautions, protective equipment and emergency procedures
Personal precautions: Avoid contact with the skin and the eyes. Avoid breathing hazardous vapors/dusts. Wear personal protective equipment. Keep away unprotected persons.
2. Environmental precautions
Suppress gases/vapours/mists with water spray jet. Do not release on the soil or into drains.
3. Methods and material for containment and cleaning up
Wash away remains with plenty of water. Transfer large quantities into a container, rinse the rest with plenty of water.
Handling and storage
Conditions of storage: Protect against heat
Preventive Precautions (fire/explosion) : Take precautionary measures against static discharges. Avoid formation of dust. Keep away from sources of ignition. Observe the usual precautionary measures required for chemicals
with dust explosive properties (Observe national regulations).
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- 2926
Shippingopen allclose all
SpecialProvisionsopen allclose all
Inland waterway transport (UN RTDG/ADN(R))
- UN number:
- 2926
Shippingopen allclose all
Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
- UN number:
- 2926
Shipping information
- Proper shipping name and description:
- Flammable solid, toxic, organic, n.o.s. ( 6-BROMO-1,2,4-TRIAZIN-3-AMINE)
- Chemical name:
- 6-Bromo-1,2,4-triazin-3-amine
- Labels:
- 4.1, 6.1
Remarksopen allclose all
Air transport (UN RTDG/ICAO/IATA)
- UN number:
- 2926
Shipping information
- Proper shipping name and description:
- Flammable solid, toxic, organic, n.o.s. ( 6-BROMO-1,2,4-TRIAZIN-3-AMINE)
- Chemical name:
- 6-Bromo-1,2,4-triazin-3-amine
- Labels:
- 4.1, 6.1
Remarksopen allclose all
SpecialProvisionsopen allclose all
Exposure controls / personal protection
Worker control:
Engineering: Appropriate containment is used in accordance with Novartis’s Global Pharma Engineering Standard which was developed in line with the IChemE Containment Standards. The 6-Bromo-1,2,4-triazin-3-amine will be charged via closed system (glovebox isolator). The plant equipment is designed, installed and validated according to industry best practice with Design Qualification (DQ), Installation Qualification, Operational Qualification and Performance Qualification (IQ,OQ,PQ) and is maintained in accordance with Engineering, Quality and HSE requirements. The design, installation and operation of the plant meet the current requirements of Good Manufacturing Practice (cGMP). All Production areas are designed and constructed with Good Engineering Practice (BATNEEC).
Administrative: A Process Risk Assessment is carried out well in advance of the Process commencing. The process Risk assessment is performed by appropriate personnel from Production, Site Services and HSE. The substance is handled under controlled conditions by experienced process technicians. All personal involved in the production must carefully study the Summary Safety Sheets (SSS) and the Safety Data Sheets (SDS) for all chemicals used in the process. The Risk Assessment is used to identify any Competence Gaps or Training Requirements. In addition there is an Internal ChemOps Competence Profile prepared for Key Positions which is used to determine Training Needs Analysis. HSE training to cover chemical handling, PPE, Access Safety Data Sheet etc. is provided. Pre campaign training is delivered to ensure operational and maintenance personnel are familiar with process hazards and chemical handling. The process is highly regulated and validated in accordance with the Health and Regulatory Authorities.
Personal: appropriate chemical-protective personal protective equipment is worn where required. Welfare facilities are provided including changing rooms and washing facilities.
Environmental control:
All wastes are incinerated in an approved, controlled furnace with combustion gas scrubbing and emission gas control.
Stability and reactivity
1. Reactivity.
Reaction products with water: None known
2. Chemical stability
Hydrolysis : no data available
3. Possibility of hazardous reactions
Materials to avoid: strong acids, strong bases
4. Conditions to avoid: ignition
5.Hazardous decomposition products: None, when used and handled as intended.
Disposal considerations
Incineration in an approved, controlled furnace with combustion gas scrubbing and emission
gas control.
Container Disposal: follow local regulations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.