Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2012-03-07 to 2012-03-15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- < 0.3
- Temp.:
- 25 °C
- pH:
- 5
- Remarks on result:
- other: 1st measurement
- Type:
- log Pow
- Partition coefficient:
- < 0.3
- Temp.:
- 25 °C
- pH:
- 5
- Remarks on result:
- other: 2nd measurement
- Type:
- log Pow
- Partition coefficient:
- < 0.3
- Temp.:
- 25 °C
- pH:
- 7
- Remarks on result:
- other: 1st measurement
- Type:
- log Pow
- Partition coefficient:
- < 0.3
- Temp.:
- 25 °C
- pH:
- 7
- Remarks on result:
- other: 2nd measurement
- Type:
- log Pow
- Partition coefficient:
- < 0.3
- Temp.:
- 25 °C
- pH:
- 9
- Remarks on result:
- other: 1st measurement
- Type:
- log Pow
- Partition coefficient:
- < 0.3
- Temp.:
- 25 °C
- pH:
- 9
- Remarks on result:
- other: 2nd measurement
- Details on results:
- Because the test material was ionisable substance, the test was performed in the pH range relevant for the natural environment (pH range of 5.0-9.0) based on OECD Guideline 117.
The test substance was found to elute before 2-butanone and thefore logPow was set at <0.3 since regression equation could not be applied.
Regression equation of calibratiion curves at mobile phase were
pH 5.0: log Pow=1.399logk-0.3575, correlation coefficient 0.99
pH 7.0 : log Pow=1.409logk-0.3721, correlation coefficient 0.99
pH 9.0 : log Pow=1.406logk-0.3704, correlation coefficient 0.99 - Conclusions:
- logPow of the test substance at pH 5.0, 7.0 and 9.0 were all found to be <0.3.
- Executive summary:
The partition coefficient of test item was determined using HPLC method based on OECD guideline 117. Because the test material was ionisable substance, the test was performed in the pH range relevant for the natural environment (pH range of 5.0 to 9.0).
logPow of the test substance at pH 5.0, 7.0 and 9.0 were all found to be <0.3.
Reference
Description of key information
The partition coefficient of test item was determined using HPLC method based on OECD guideline 117. Because the test material was ionisable substance, the test was performed in the pH range relevant for the natural environment (pH range of 5.0 to 9.0).
logPow of the test substance at pH 5.0, 7.0 and 9.0 were all found to be <0.3.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.3
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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