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EC number: 939-511-7 | CAS number: 1064698-37-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
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- Nanomaterial pour density
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- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
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- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data
Henry's Law constant
Administrative data
- Endpoint:
- Henry's law constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 8 Nov-15 Nov 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in accordance with GLP standards and ETS-8-182, which is deemed appropriate for measurement of this endpoint.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Deviations:
- no
- Principles of method if other than guideline:
- Based on EPA method 8260A
- GLP compliance:
- yes
Test material
- Reference substance name:
- FC-43
- IUPAC Name:
- FC-43
- Details on test material:
- - Name of test material (as cited in study report): FC-43 (perluorotributylamines), Perfluorotributylamines (PFTBA)
- Physical state: Colorless, clear liquid
- Analytical purity: 98.85%
Constituent 1
Results and discussion
Henry's Law constant H
- H:
- > 166 000 dimensionless - volumetric basis
- Temp.:
- 22 °C
Any other information on results incl. tables
Henry's Law constant (kH,cc) result is reported a dimensionless ratio of vapor phase concentration of FC-43 over aqueous phase concentration. From Table 10, the overall average kH,cc for the experiment was determined to be 166000. This quantity was used to express Henry's Law constants in conventional units which represent volatility. This can be done using the ideal gas law as follows:
kH,cc = Cg/Ca = kH,pc*RT
where kH,cc is the dimensionless Henry's Law constant, Cg is the concentration of the test substance in the gas phase, Ca is the concentration of test substance in the aqueous phase, kH,pc is the Henry's Law constant representing volatility, R is the ideal gas constant, and T is temperature in kelvin. Using the overall average dimensionless kH,cc for the experiment and average daily temperature of 22 °C (295 K), the Henry's Law constant can be expressed as 4020 atm m³/mol (4.07E+08 Pa m³/mol).
By including samples with different volumes of water and air and available glass surface, the study demonstrated that wall effects or slow mass transfer do not significantly affect the observed results:
kH,cc(FC-43) | |||||
Day 1 | Day 2 | Day 3 | Day 6 | ||
70% Headspace | Rep 1 | >208000 | >250000 | 833002 | NR1 |
Rep 2 | 826002 | >285000 | 693002 | >309000 | |
Average | 82600 | >250000 | 76300 | >309000 | |
%RPD | NA | NA | 18 | NA | |
50% Headspace | Rep 1 | 1270003 | 2370003 | >246000 | >364000 |
Rep 2 | >182000 | 2170003 | >257000 | 2670003 | |
Average | 127000 | 227000 | >246000 | 267000 | |
%RPD | NA | 8.8 | NA | NA | |
30% Headspace | Rep 1 | 1720002 | 2230002 | 381002 | >169000 |
Rep 2 | >185000 | >264000 | 1480002 | 3240003 | |
Average | 172000 | 223000 | 223000 | 324000 | |
%RPD | NA | NA | 49 | NA | |
Intra-Day Average | 127000 | 226000 | 84700 | 296000 | |
N measured values | 3 of 12 | 3 of 12 | 4 of 12 | 2 of 12 | |
%RSD | 35 | 4.5 | 55 | 19 | |
Overall Average | 166000 | ||||
%RSD | 54 |
(1) Not reported due to data outliers.
(2) The concentration of both aliquots of the water phase were above the Limit of Quantitation. The average result was used to calculate log(kH,cc).
(3) The concentration of one of two aliquots of the water phase from this replicate was above the Limit of Quantitation. The higher result was used to calculate log(kH,cc) and therefore should be considered a minimum value.
Applicant's summary and conclusion
- Conclusions:
- The measured Henry's Law constant for FC-43 was determined to be greater than 4020 atm m³/mol at 22 °C
- Executive summary:
The study reports a measured dimensionless Henry's Law constant of 166000 at an average daily temperature of 22 °C, which is expressed as the ratio of vapor phase concentration of FC-43 over aqueous phase concentration. As per Appendix R.7.1-4 Henry's law constant and evaporation rate, it is customary to find these constants reported as the ratio of vapor phase partial pressure over aqueous phase concentration in units of atm m³/mol. The Henry's Law constant expressed in conventional units is greater than 4020 atm m³/mol at 22 °C.
FC-43 kH,cc values were determined for individual replicates for each headspace ratio (approximately 30%, 50%, and 70%) at each time point (Day 1, Day 2, Day 3, and Day 6) to ensure that equilibrium conditions were obtained. The study was performed according to 3M Environmental Lab Protocol GLP11-0007, which is based on scientifically valid methods derived from published methods. Samples were analyzed using purge and trap GC/MS according to 3M Environmental Lab Method ETS-8-182 "Analysis of Volatile organic Compounds using Purge and Trap and Gas Chromatography/Mass Spectrometry". Henry's Law constant was also separately measured at three time points for two substances (TFE and OFCB) that have values reported in literature to document that the analytical techniques developed are suitable for this analysis. The kH,cc for TFE and OFCB determined in this study agreed within 15% of the literature reported values demonstrating suitability of the method applied to the test substance. No OECD guideline exists for measuring Henry's Law constants. The study was conducted in accordance with GLP standards and ETS-8-182, which is deemed appropriate for measurement of this endpoint. Therefore this study is classified as reliable without restrictions.
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