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Diss Factsheets
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EC number: 700-043-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Remarks:
- assessment of toxicokinetic behavior
- Type of information:
- other: an assessment of toxicokinetic behavior has been conducted to the extent that can be derived from the relevant available information.
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Relevant studies were reviewed with a view to fulfilling the requirements of Annex VIII (8.8.1).
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In accordance with REACH Annex VIII (8.8.1) an assessment of toxicokinetic behavior has been conducted to the extent that can be derived from the relevant available information.
- Conclusions:
- Interpretation of results (migrated information): high bioaccumulation potential based on study results
Reference
Test material: OH-mPDMS
The test material consists of two ester groups, a relatively high molecular weight colourless liquid. The low vapour pressure value shows that the test material is not volatile therefore exposure to volatile products, via inhalation is unlikely. The test material is expected to undergo hydrolysis under physiological conditions which means that the parental compound may only be present in the gastro-intestinal or respiratory tracts for a limited period of time. Besides to this, the test material is not readily biodegradable which means that exposure to degradants, following oral ingestion is unlikely to occur. The test material has a high log octanol/water partition coefficient value that suggests that the substance is a high lipophilic compound which would pass across biological membranes and be absorbed by micellular solubilisation.
Absorption
The results of the acute and repeated oral toxicity studies in the rat show that the test material is either of low inherent toxicity or there is no significant absorption of the parent material. The possible lack of absorption may be a consequence of the hydrolysis of the test material under physiological conditions. The physical properties of the test material such as high molecular weight, high log Pow, low water solubility groups would not allow absorption of parental compound from the gastro-intestinal tract and the skin. Low volatility of the substance suggests that the test material would not be available for inhalation. The results of an acute dermal toxicity study in the rat show no significant toxicity, which may suggest a lack of toxicity, or that the skin is not a significant route of exposure due to low volatility of the test substance.
Distribution
There is no significant evidence to suggest that there is systemic distribution of the test material. The evidence of a positive response from the guinea pig skin sensitisation study can suggest that the test material might bind to proteins in the circulatory system. The high log octanol/water partition coefficient and non-degradability may suggest that the test material may distribute into cells and accumulate in body fat.
Metabolism
The results of the repeat oral toxicity study in the rat did not show any evidence of enhanced metabolism. The test material does not readily degrade and therefore it is likely to require further metabolism prior to excretion. The results of thein vitrogenotoxicty studies show that genotoxicity is neither enhanced nor diminished in the presence of S9 metabolising system.
Excretion
There is no evidence to indicate the route of excretion but poor water-soluble products with high molecular weights are not favourable for urinary excretion. Any test material that is not absorbed will be excreted in the faeces.
Description of key information
See discussion.
Key value for chemical safety assessment
- Bioaccumulation potential:
- high bioaccumulation potential
Additional information
Test material: OH-mPDMS
The test material consists of two ester groups, a relatively high molecular weight colourless liquid. The low vapour pressure value shows that the test material is not volatile therefore exposure to volatile products, via inhalation is unlikely. The test material is expected to undergo hydrolysis under physiological conditions which means that the parental compound may only be present in the gastro-intestinal or respiratory tracts for a limited period of time. Besides to this, the test material is not readily biodegradable which means that exposure to degradants, following oral ingestion is unlikely to occur. The test material has a high log octanol/water partition coefficient value that suggests that the substance is a high lipophilic compound which would pass across biological membranes and be absorbed by micellular solubilisation.
Absorption
The results of the acute and repeated oral toxicity studies in the rat show that the test material is either of low inherent toxicity or there is no significant absorption of the parent material. The possible lack of absorption may be a consequence of the hydrolysis of the test material under physiological conditions. The physical properties of the test material such as high molecular weight, high log Pow, low water solubility groups would not allow absorption of parental compound from the gastro-intestinal tract and the skin. Low volatility of the substance suggests that the test material would not be available for inhalation. The results of an acute dermal toxicity study in the rat show no significant toxicity, which may suggest a lack of toxicity, or that the skin is not a significant route of exposure due to low volatility of the test substance.
Distribution
There is no significant evidence to suggest that there is systemic distribution of the test material. The evidence of a positive response from the guinea pig skin sensitisation study can suggest that the test material might bind to proteins in the circulatory system. The high log octanol/water partition coefficient and non-degradability may suggest that the test material may distribute into cells and accumulate in body fat.
Metabolism
The results of the repeat oral toxicity study in the rat did not show any evidence of enhanced metabolism. The test material does not readily degrade and therefore it is likely to require further metabolism prior to excretion. The results of thein vitrogenotoxicty studies show that genotoxicity is neither enhanced nor diminished in the presence of S9 metabolising system.
Excretion
There is no evidence to indicate the route of excretion but poor water-soluble products with high molecular weights are not favourable for urinary excretion. Any test material that is not absorbed will be excreted in the faeces.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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