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Diss Factsheets
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EC number: 700-161-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral: OECD 425, LD50 female rats, no adverse effects observed. Not classified as acutely toxic by the oral route. Reliability = 1.
Dermal: OECD 402. LD50, rat. No adverse effects observed. Not classified as acutely toxic by the dermal route. Reliability = 1.
Inhalation: 47 mg a.i./m3 bw. Lethality, pulmonary edema. Aqueous dispersion of TNS administered, Determination of threshold for lethality, Classification for acute toxicity by inhalation is proposed. Reliability = 2
Key value for chemical safety assessment
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- discriminating conc.
- Value:
- 47 mg/m³
Additional information
The Notified Substance (TNS) was tested for acute oral, dermal and inhalation toxicity. The aqueous dispersion of TNS (~20% solids and ~80% water) was administered directly without correction for active ingredient since the product does not exist as TNS alone and is always transported and used as the aqueous dispersion. The material was not toxic via the oral or dermal routes of exposure as evidenced by LD50 values of > 5000 mg/kg. This is equivalent to an approximate LD50 > 1000 mg a. i. / kg or TNS, as the aqueous dispersion was administered in this study. An acute inhalation toxicity study was conducted on this multi-constituent substance. The Approximate Lethal Concentration (ALC) or threshold for lethality was the resulting endpoint from this study and was determined to be 47 mg a. i. /m3 (respirable particulate), indicating the material may be toxic upon inhalation of respirable particulate (aerosol). TNS is not expected to be present in the vapour form, therefore it would not pose the same hazard. A full LC50 evaluation has not been conducted on this material nor any similar substance. However, an acute toxicity estimation (ATE) can be used to determine a classification category. Therefore, the ATE is 0.005 mg/L and this value will be used to make an acute inhalation classification.
Justification for classification or non-classification
The TNS is not classified for acute oral toxicity as the LD50 was determined to be > 1000 mg a. i. /kg and the LD50 for Zonyl was > 25,000 mg/kg. Similarly, it is not classified for dermal toxicity as the LD50 for this route of exposure was also > 1000 mg a. i. /kg and given the very low bioavailability as evidenced by a lack of toxic effects in the Zonyl acute and subchronic exposure studies. TNS does not need to be classified for acute oral or dermal toxicity according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008. A full LC50 determination has not been made for this substance nor for any similar substance, however, the ATE of 0.005 mg/L, indicates the CLP classification of Cat. 1 should be used for classification of this material.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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