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EC number: 607-240-0 | CAS number: 23511-73-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 Dec 2008 - 8 Jan 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Activated sludge was obtained from the municipal sewage treatment plant "Waterschap de Maaskant", ('s-Hertogenbosch, The Netherlands), which received predominantely domestic sewage.
- Storage conditions: The activated sludge was kept under continuous aeration until further treatment.
- Preparation of inoculum for exposure: Before use, the sludge was allowed to settle (34 min.) and the liquid was decanted for use as inoculum.
- Water filtered: yes
- Type and size of filter used, if any: Tap-water was purified by reverse osmosis (Milli-RO) and subsequently passed over activated carbon and ion-exchange cartridges (Milli-Q) - Duration of test (contact time):
- 28 d
- Initial conc.:
- 12 mg/L
- Based on:
- other: TOC
- Initial conc.:
- 16.5 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: as recommended in guideline
- Test temperature: 21.5 - 22.2 °C
- pH: 7.6 - 7.9
- pH adjusted: no
- Aeration of dilution water: continuously
- Suspended solids concentration: 4.1 g/L
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 2 L all-glass brown coloured bottles
- Number of culture flasks/concentration: 2
- Method used to create aerobic conditions: CO2-free air was passed through the test vessel at a rate of ~ 1-2 bubbles per second (~ 30-100 mL/min.).
- Measuring equipment: The amount of CO2 produced was determined by titrating the remaining Ba(OH)2 with 0.05 M standardized HCl.
- Details of trap for CO2 and volatile organics if used: Three CO2 absorbers (bottles filled with 100 mL 0.0125 M Ba(OH)2) were connectedin series to the exit air line of each test bottle.
SAMPLING
- Sampling frequency: On days 2, 5, 7, 9, 14, 19, 23, 27 and 29.
- Sampling method: The CO2-absorber nearest to the test bootle was removed for titration (each of the remaining two absorbers was moved one position in the direction of the test vessel and a new one was placed at the end of the series).
CONTROL AND BLANK SYSTEM
- Inoculum blank: 2
- Positive control: 1
- Toxicity control: 1 - Reference substance:
- benzoic acid, sodium salt
- Remarks:
- 12 mg/L TOC
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 81
- Sampling time:
- 28 d
- Remarks on result:
- other: average of two replicates: 86%, 77%
- Details on results:
- The test substance reached a biodegradation of > 60% within 28 days, but the 10 day-window criterion was not met. Thus, the test substance is readily biodegradable but failing the ten day window according to OECD criteria. Based on the permanently increasing degradation curve during the test period and the high biodegradation rate of 81% achieved within 28 days, the test substance can be considered as biodegradable.
- Results with reference substance:
- The reference substance was degraded to 64% in 28 days.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable, but failing 10-day window
Reference
In the toxicity control more than 25% biodegradation occurred within 14 days (51% based on hCO2). Therefore, the test substance was assumed not to inhibit microbial activity.
Table 1: Biodegradation of blank and test substance (bottle 1 and 2)
Day |
Cumulative CO2 [mg] |
Biodegradation [%] |
|||
Blank |
Bottle 1 |
Bottle 2 |
Bottle 1 |
Bottle 2 |
|
2 |
2.1 |
0.0 |
0.3 |
0 |
0 |
5 |
5.8 |
11.6 |
9.7 |
13 |
11 |
7 |
8.3 |
18.2 |
15.4 |
21 |
17 |
9 |
11.5 |
24.5 |
19.8 |
28 |
22 |
14 |
16.9 |
38.0 |
33.7 |
43 |
38 |
19 |
22.7 |
59.8 |
55.2 |
68 |
62 |
23 |
29.5 |
68.3 |
63.1 |
78 |
71 |
27 |
35.6 |
73.0 |
66.8 |
83 |
75 |
29 |
45.5 |
75.5 |
67.9 |
86 |
77 |
Description of key information
Readily biodegradable but failing 10-day window: 81% in 28 days (OECD 301B)
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
The biodegradability of 2-Phenoxyethyl octanoate (CAS 23511-73-1) was tested according to OECD guideline 301B. The initial test substance concentration was 16.5 mg/L (12mg/L based on TOC) Non-adapted effluent obtained from a STP predominately treating domestic sewage was used as inoculum. Based on the CO2 evolution a mean degradation rate of 81% was observed after 28 days (mean of two replicates with 86% and 77%). The degradation rate did not reach the pass level of 60% removal of DOC within the 10-day window. Therefore, the substance is considered readily biodegradable but failing 10-day window.
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