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Diss Factsheets
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EC number: 918-811-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was given a reliability rating of 1 because it followed a standard test guideline, which describes a procedure to evaluate this endpoint, and the results were reviewed for reliability and assessed as valid. The study was also conducted under GLP.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- Individual treatment solutions were prepared as Water Accommodated Fractions (WAFs). This included adding test substance to glass vessels,
which contained dilution water and mixing for approximately 24 hours with a magnetic stirrer to produce a series of geometrically-spaced
loading rates (mg/L). After mixing, the WAFs were allowed to settle for an hour. Each aqueous phase was then drawn off and transferred to two
150 mL Erlenmeyer flasks which were completely filled. Two further flasks were filled with dilution water only and served as controls. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Organisms were supplied by in-house cultures. The laboratory culture is derived from a clone held at ICI Brixham Laboratory. The ICI clone was
itself obtained from the Institut de Recherche Chimique Applique (I.R.Ch.A.), France. Test organisms age = <24 hours old; parents age = 15 - 28
days. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- Water hardness of the control dilution water was 174 mg/L as CaCO3.
- Test temperature:
- Test temperature was 20 – 22 ºC.
- pH:
- The pH ranged from 7.7 to 8.1.
- Dissolved oxygen:
- Dissolved oxygen was 8.3 to 8.6 mg/L for "new" solutions and 8.6 to 8.7 mg/L for "old" solutions.
- Salinity:
- freshwater
- Nominal and measured concentrations:
- Nominal treatment levels were control, 0.1, 0.4, 1.0, 3.0 and 10 mg/L, which at t=0 measured non detected (< 2.5 mg/L), NA (not analyzed), NA, NA,
3.3 mg/L and 8.2 mg/L, respectively. - Details on test conditions:
- Ten Daphnia magna, less than 24 h old, were added to each flask. The flasks were sealed with black caps that excluded air from the vessel. After
24 and 48 h the numbers of immobilized D.magna were recorded. D.magna were considered to be immobile, if, when the contents of the flask were
swirled they did not swim during a 15 second period of observation.
Photoperiod with a 16 h : 8 h light : dark lighting regime. - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- >= 3 - <= 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- See Table in Remarks on Results
- Reported statistics and error estimates:
- Loading rates causing a 50% effect were determined by visual inspection of the data. They are expressed as being within a range bounded by loading rates that were tested. This is considered more appropriate for test materials that are mixtures of substances of different solubilities than is an interpolative statistical technique.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Water accommodated fractions of hydrocarbons, C10, aromatics, >1% naphthalene, produced a 48-hour LL50 value between 3 and 10 mg/L with Daphnia magna.
- Executive summary:
Water accommodated fractions of hydrocarbons, C10, aromatics, >1% naphthalene, produced a 48-hour LL50 value between 3 and 10 mg/L with Daphnia magna.
Reference
Nominal Loading | Measured Conc | Daphnia Immobilized |
(mg/L) | (mg/L) | (@ 24, 48 hrs)* |
Control | <LoD | 0,0 |
0.1 | <LoD | 0, 0 |
0.4 | <LoD | 0, 0 |
1.0 | <LoD | 0, 0 |
3.0 | 3.3 – 3.1 ** | 0, 0 |
10.0 | 8.2 – 7.8 ** | 10, 10 |
*10 daphnids added to each of the control and treatment levels (both in duplicate) at test initiation
** Measured concentrations refer to the t=0h (fresh) and t=48 h (old) samples
Description of key information
There is no data available for Hydrocarbons, C10, aromatics, <1% naphthalene. However, data is available for a structural analogue, Hydrocarbons, C10 aromatics, >1% naphthalene and presented in the dossier. This data is read across to based on analogue read across and a discussion and report on the read across strategy is provided as an attachment in IUCLID Section 13.
Water accommodated fractions of hydrocarbons, C10, aromatics, >1% naphthalene, produced a 48-hour LL50 value between 3 and 10 mg/L with Daphnia magna.
In a supporting study, water accommodated fractions of hydrocarbons, C10, aromatics, >1% naphthalene, produced a 48-hour LL50 value of 10 mg/L with Daphnia magna.
Key value for chemical safety assessment
Additional information
Water accommodated fractions of hydrocarbons, C10, aromatics, >1% naphthalene, produced a 48-hour LL50 value between 3 and 10 mg/L with Daphnia magna.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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