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Diss Factsheets
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EC number: 603-006-7 | CAS number: 124728-62-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Objective of study:
- other: Repeated Dose and Reproductive Screening Toxicity Study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 422
- GLP compliance:
- yes (incl. QA statement)
- Type:
- absorption
- Results:
- well absorbed
- Type:
- distribution
- Results:
- systemically distributed
- Metabolites identified:
- no
Reference
Resorption
Because of the molecular structure, low molecular weight and octanol-water partition coefficient (>6.5), resorption of the test item via the gastrointestinal tract is considered to be likely. After single treatment of rats with the test item at a dose of 2000 mg/kg bw no signs of toxicity were observed (acute oral: key study).
Data from a subacute study are available. Daily oral treatment with 100, 300 and 1000 mg/kg bw/d of this test item to rats was clinically tolerated over 28 days. Dose-related changes were observed in liver, comprising increased hepatic weights and correlating hepatocellular hypertrophy, and in the thyroid gland, i.e. follicular cell hypertrophy. Based on these systemic findings it can be concluded that the substance is well absorbed after oral administration.
Distribution
The toxicological effects found in the repeat dose toxicity study of the test item (OECD 422: key study) clearly show that this compound is distributed throughout the body after oral uptake and is thus systemically available.
Metabolism and Excretion
Specific information on the metabolism and excretion of the substance is not available. From the subacute study it can be conclududed, that metabolism in the liver can be assumed as a tendency towards an increase of absolute and relative liver weights at 1000 mg/kg bw/d was found. The liver weight changes did not show a clear dose-response-relationsship. Only minimal degree of hepatocellular hypertrophy have ben noted at 1000 mg/kg bw/d, therefore the slight changes are considered non adverse. Due to the molecular properties, excretion via the kidneys is considered to be the main route of elimination.
Description of key information
Resorption
Because of the molecular structure, low molecular weight and octanol-water partition coefficient (>6.5), resorption of the test item via the gastrointestinal tract is considered to be likely. After single treatment of rats with the test item at a dose of 2000 mg/kg bw no signs of toxicity were observed (acute oral: key study).
Data from a subacute study are available. Daily oral treatment with 100, 300 and 1000 mg/kg bw/d of this test item to rats was clinically tolerated over 28 days. Dose-related changes were observed in liver, comprising increased hepatic weights and correlating hepatocellular hypertrophy, and in the thyroid gland, i.e. follicular cell hypertrophy. Based on these systemic findings it can be concluded that the substance is well absorbed after oral administration.
Distribution
The toxicological effects found in the repeat dose toxicity study of the test item (OECD 422: key study) clearly show that this compound is distributed throughout the body after oral uptake and is thus systemically available.
Metabolism and Excretion
Specific information on the metabolism and excretion of the substance is not available. From the sbacute study it can be conclududed, that metabolism in the liver can be assumed as a tendency towards an increase of absolute and relative liver weights at 1000 mg/kg bw/d was found. The liver weight changes did not show a clear dose-response-relationsship. Only minimal degree of hepatocellular hypertrophy have ben noted at 1000 mg/kg bw/d, therefore the slight changes are considered non adverse. Due to the molecular properties, excretion via the kidneys is considered to be the main route of elimination.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.