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EC number: 500-005-2 | CAS number: 9003-35-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity:
The acute oral toxicity dose (LD50) was considered based on different studies conducted on rats and mice for the test chemical. The LD50 value is >5000 mg/kg bw, for acute oral toxicity. Thus, comparing this value with the criteria of CLP regulation, the given test chemical cannot be classified for acute oral toxicity.
Acute Inhalation Toxicity:
The acute Inhalation toxicity dose (LC50) was considered based on different studies conducted on rats and mice for the test chemical. The studies concluded that the LC50 value is >5 mg/L (>5000 mg/m3), for acute inhalation toxicity. Thus, comparing this value with the criteria of CLP regulation, the given test chemical cannot be classified for acute inhalation toxicity.
Acute Dermal toxicity:
The acute dermal toxicity dose (LD50) was considered based on different studies conducted on rats and rabbits for the test chemical. The studies concluded that the LD50 value is >2000 mg/kg bw, for acute dermal toxicity. Thus, comparing this value with the criteria of CLP regulation, the given test chemical cannot be classified for acute dermal toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from authoritative database
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of test chemical was performed in rats
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- yes
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data available
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No data available
- Doses:
- As mentioned in table below
- No. of animals per sex per dose:
- Total :10
male:5
female:5 - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily
- Necropsy of survivors performed: No data available
- Other examinations performed: clinical signs and postmortem examination
Were performed - Statistics:
- No data available
- Preliminary study:
- No data available
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- Acute oral studies indicate that LD50 values of test chemical in the rat are proportional to their free test substance content.
- Interpretation of results:
- other: Not classified
- Conclusions:
- The LD50 value was considered to be >5000 mg/kg,when male and female rats were treated with test chemical orally.
- Executive summary:
Acute oral toxicity test was carried out for different grades of test chemical. Groups of five male and five female rats were given single oral doses of the test materials. The animals were observed at frequent intervals for the first day and then at least daily over a 14-day observation period. All the animals dying during this period and the surviving animals, which were killed on day 14, were subjected to a post mortem examination to note any microscopic abnormalities.Administration of different grades of test chemical in male and female rat resulted in no or minimum, sign of toxicity at doses up to 5000 mg/kg. Hence,The LD50 value was considered to be >5000 mg/kg,when male and female rats were treated with test chemical orally.
Reference
SR.NO |
Resin type |
Clinical signs |
|
1 |
Phenol Formaldehyde Novolak Ground With Hexamine (6%) |
Tremors and convulsion in animal subsequent prostration with twitching and staining around the mouth & chin. |
|
2 |
Phenol Formaldehyde Novolak Ground With Hexamine (9.1%) |
Nothing abnormal detected. |
|
3 |
Ground Phenol Formaldehyde Novolak Without Hexamine |
Nothing abnormal detected. |
|
4 |
Cashew Modified Phenol Formaldehyde Novolak Ground With Hexamine (7. 9%) |
Slight Tremors in 4 animals. Salivation and resultant fur staining with evidence of gastro-intestinal disturbance. |
|
5 |
Spray Dried Phenol Formaldehyde Resol |
Seadation, Ruffled fur and arched posture. |
|
6 |
Resorcinol Phenol Formaldehyde Novolak In Ethanol (7. 5%) |
Seadation and convulsion with Ruffled fur and arched posture. |
|
7 |
Phenol Formaldehyde Resol In Ethanol (43%) |
Nothing abnormal detected. |
|
8 |
Phenol Formaldehyde Resol In Ethanol (19. 7%) |
Seadation and convulsion with Ruffled fur and arched posture. |
|
9 |
Phenol Formaldehyde Resol In Ethanol (30%) |
Transient salivation and transient staining. |
|
10 |
Water Dilutable Phenol Formaldehyde Liquid Resol |
Transient salivation (with associated staining) and body Tremors at all dose level. Some staining in urogenital region. |
|
11 |
Phenol Formaldehyde Liquid Resol |
Seadation, Ruffled fur, arched posture. Some convulsion at highest dose level |
|
12 |
Phenol Formaldehyde Liquid Resol |
Transient salivation and associated staining slight body tumor in one animal. |
|
13 |
Phenol Formaldehyde Liquid Resol |
Tumors and convulsion with prostration and twitching at both dose level. Salivation was seen in almost all animals. No treatment related microscopic change at autopsy in all surviving animals |
|
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from authoritative database.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of various test substances
- Justification for type of information:
- Data for the test chemical is summarized based on the various chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- WoE report is based on 2 acute inhalation toxicity studies as - WoE-2 and WoE-3
Acute Inhalation toxicity test was carried out to study the effects of the test chemicals on rodents. - GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
- Species:
- other: 1. mouse 2. rat
- Strain:
- other: 1. not specified 2. not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- 1. not specified
2. not specified - Route of administration:
- other: 1. inhalation: vapour 2. inhalation
- Type of inhalation exposure:
- other: 1. not specified 2. not specified
- Vehicle:
- other: 1. not specified 2. not specified
- Remark on MMAD/GSD:
- 1. not specified
2. not specified - Details on inhalation exposure:
- 1. not specified
2. not specified - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 2 h
- Remarks on duration:
- not specified
- Concentrations:
- 1. Range between 2,000 and 17,000 mg/m³
2. 5 mg/l in air (5000 mg/m3) - No. of animals per sex per dose:
- 1. not specified
2. not specified - Control animals:
- not specified
- Details on study design:
- 1. - Necropsy of survivors performed: yes
- Other examinations performed: Animals were observed for mortality and clinical signs.
2. not specified - Statistics:
- 1. not specified
2. not specified - Preliminary study:
- 1. not specified
2. not specified - Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 7 570 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 2 h
- Remarks on result:
- other: 50% mortality was observed
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 5 mg/L air
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- 1. 50% mortality was observed
2. No mortality was observed at dose 5 mg/l in air in treated rats - Clinical signs:
- other: 1. Initially all animals exhibited slight inflammations of the eyes and the respiratory tract as well as agitation, followed by a loss of activity. After exposures to values up to 4,000 mg/m³ these symptoms were reversible after the termination of the exp
- Body weight:
- 1. not specified
2. not specified - Gross pathology:
- 1. The dissection revealed injuries in several organs (vascularisation, bleeding, dystrophic changes).
2. not specified - Other findings:
- 1. not specified
2. not specified - Interpretation of results:
- other: Not classified
- Conclusions:
- According to CLP regulation the test chemical cannot be classified for acute inhalation toxicity, as the LC50 value is >5 mg/L (>5000 mg/m3).
- Executive summary:
In different studies, the given test chemical has been investigated for acute inhalation toxicity to a greater or lesser extent. Often are the studies based on in-vivo experiments in rodents, i.e. most commonly in rats and mice for test chemical. The studies are summarized as below -
The acute inhalation toxicity study was conducted by using test chemical in mice at the concentration range between 2,000 and 17,000 mg/m³. Animals were observed for mortality and clinical signs. Necropsy was performed. 50% mortality was observed in treated mice at 7570 mg/m³ when exposed for 2 hours. Initially all animals exhibited slight inflammations of the eyes and the respiratory tract as well as agitation, followed by a loss of activity. After exposures to values up to 4,000 mg/m³ these symptoms were reversible after the termination of the exposure. Higher concentrations caused further CNS and neuromuscular symptoms (weak reflexes, unsteady gait, respiratory disorders, and tonic-clonic spasms). The dissection revealed injuries in several organs (vascularisation, bleeding, dystrophic changes). Therefore, LC50 was considered to be 7570 mg/m³, when mice were exposed to test chemical via inhalation by vapour for 2 hour exposure.
The above study is supported with another study conducted on rats for the test chemical. The acute inhalation toxicity study was conducted by using test chemical in rats at the concentration of 5000 mg/m3 inhaled as a Single dose. No mortality was observed at 5000 mg/m3. Therefore, LC50 value was considered to be >5000 mg/ m3 (>5 mg/L) when rats were exposed with test chemical by inhalation route.
Thus, based on the above summarised studies on test chemical, it can be concluded that LC50 value is >5 mg/L (>5000 mg/m3). Thus, comparing this value with the criteria of CLP regulation, the given test chemical cannot be classified for acute inhalation toxicity.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 7 570 mg/m³ air
- Quality of whole database:
- Data is Klimisch 2 and from authoritative database.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from authoritative database
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity study of test chemical was performed in rats
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- yes
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data available
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- 24hr
- Doses:
- As mentioned in table below
- No. of animals per sex per dose:
- Total :10
male:5
female:5 - Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data available
- Necropsy of survivors performed: No data available
- Other examinations performed: clinical signs, body weight, histopathology were observed
other: To prevent the animals from gaining access to the sites of application (and hence
Probably ingesting the test material) acetate collars were placed around each rat's neck for a further 24 hours. - Statistics:
- No data available
- Preliminary study:
- No data available
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was not observed at given dose
- Mortality:
- Mortality observed only for test chemical In IHS (7. 5%).
At 2000 mg/kg- 3/10
At 2500 mg/kg - 9/10
At 3000 mg/kg - 9/10
At 4000 mg/kg - 10/10 - Clinical signs:
- other: As mentioned in table below
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- other: Not classified
- Conclusions:
- The LD50 value was considered to be >2000mg/kg bw, when rats were treated with test chemical by dermal application
- Executive summary:
Acute dermal toxicity test was carried out for different grades of test chemical. Groups of five male and five female rats were exposed to single doses of selected resin applied to the skin under occlusion for 24 hours.A similar group, exposed to the patches alone, served as controls.The animals were observed for 14 days following exposure for signs of toxicity.No fatalities occurred, except at the higher treatment levels with test chemical in ethanol containing 23% free phenol, during the observation period although evidence of irritancy was noted with certain grades. Bodyweight gain was essentially similar in treated and control animals and no significant macroscopic changes were seen in the organs at autopsy.Dermal LD values for all the grades examined under the conditions of exposure, considered to exceed 2000 mg/kg. Hence, The LD50 value was considered to be >2000mg/kg bw, when rats were treated with test chemical by dermal application.
Reference
SR.NO |
Resin type |
Clinical signs |
1 |
Unground Phenol Formaldehyde resol |
Slight sedation and ruffled fur. Mild redness swelling on test site. |
2 |
Resorcinol Phenol Formaldehyde Novolak In IHS (7. 5%) |
Sedation and ruffled fur. mild redness swelling on test site |
3 |
Phenol Formaldehyde Resol In Ethanol (43%) |
Nothing abnormal detected |
4 |
Phenol Formaldehyde Resol In IHS (19. 7%) |
Slight sedation and ruffled fur. and curved posture |
5 |
Phenol Formaldehyde liquid Resol |
Sedation and ruffled fur. mild redness swelling on test site |
6 |
Phenol Formaldehyde liquid Resol |
Nothing abnormal detected. Skin stained at test site |
7 |
Water Dilutable Phenol Formaldehyde Liquid Resol |
Nothing abnormal detected. Well depend redness on test site on female animals for 24 hrs following patches removal. |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from authoritative database.
Additional information
Acute oral toxicity:
In different studies, the given test chemical has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in-vivo experiments in rodents,
i.e. most commonly in rats and mice for test chemical. The studies are summarized as below –
Acute oral toxicity test was carried out for different grades of test chemical. Groups of five male and five female rats were given single oral doses of the test materials. The animals were observed at frequent intervals for the first day and then at least daily over a 14-day observation period. All the animals dying during this period and the surviving animals, which were killed on day 14, were subjected to a post mortem examination to note any microscopic abnormalities. Administration of different grades of test chemical in male and female rat resulted in no or minimum, sign of toxicity at doses up to 5000 mg/kg. Hence, the LD50 value was considered to be >5000 mg/kg, when male and female rats were treated with test chemical orally.
The above study is supported with another study for the test chemical. The acute oral toxicity test was conducted on rat to evaluate the lethal dose of test chemical. The Sprague dawley rats were dosed orally with dose concentration of 2510, 3160, 3980 and 5010 mg/kg to 20 male and female rats for 14 days. Body weight, mortality, clinical signs and gross pathology changes were observed. Mortality was observed on day 1. Weight loss in survivors, increasing weakness, salivation, ocular discharge, dyspnes, collapse and death occurred in the animals during study period. In gross pathology, Hemorrhagic lungs, liver discoloration, and acute gastrointestinal inflammation observed.50% mortality was observed at dose 2900 mg/kg. Hence, based on mortality, LD50 value was considered to be 2900 mg/kg bw, when rats were treated with test chemical orally.
These studies are supported with the study mentioned in database for the test chemical. The acute oral toxicity study was performed by using test chemical in male albino rats at the dose concentrations of 2150, 3160, 4640, 6810 and 10000 mg/kg bw. The given test chemical was dissolved as 0.5% solution of methylcellulose and administered via oral gavage route. The animals were observed for mortality and clinical signs for 7 days. Necropsy of survivors performed. Thompson moving average method was used to calculate LD50 value.
Death was preceded by coma. Animals at all dosage levels appeared depressed and exhibited lachrymation; ataxia; sprawling of the hind limbs; prone positions; depressed or absent placement, pain, and righting reflexes; tachycardia; and rapid and labored respiration. In addition, salivation was observed among the animals at the four higher dosage levels. The surviving animals appeared slightly depressed and exhibited slight lacrimation 24 hours following oral administration. At 48 hours, and daily thereafter, the surviving animas appeared normal. Gross pathology revealed the following observation, hemorrhagic lungs, irritation of the gastrointestinal tract and peritoneous, and congested kidneys and adrenals. Under the condiction of this, the lethal concentration (LD50) value for acute oral toxicity test was considered to be 3830 mg/kg bw (95% CI: 2930-5000 mg/kg bw), when male albino rats were treated with test chemical orally via gavage.
All the above studies are further supported with the study mentioned in database for the test chemical. The acute oral toxicity study of test chemical was conducted on mouse at the dose concentration of 9000 mg/kg bw. The test chemical was administered via oral route. All animals were maintained under close observation for recording toxic signs and time of death. Mortality was observed at a dose of 9000 mg/kg bw. Therefore, LD50 value was considered to be 9000 mg/kg bw, when mouse were treated with test chemical via oral route.
Thus, based on the above summarised studies on test chemical, it can be concluded that LD50 value is >2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, the given test chemical cannot be classified for acute oral toxicity.
Acute Inhalation Toxicity:
In different studies, the given test chemical has been investigated for acute dermal toxicity to a greater or lesser extent. Often are the studies based on in-vivo experiments in rodents, i.e. most commonly in rats and mice for test chemical. The studies are summarized as below -
The acute inhalation toxicity study was conducted by using test chemical in mice at the concentration range between 2,000 and 17,000 mg/m³. Animals were observed for mortality and clinical signs. Necropsy was performed. 50% mortality was observed in treated mice at 7570 mg/m³ when exposed for 2 hours. Initially all animals exhibited slight inflammations of the eyes and the respiratory tract as well as agitation, followed by a loss of activity. After exposures to values up to 4,000 mg/m³ these symptoms were reversible after the termination of the exposure. Higher concentrations caused further CNS and neuromuscular symptoms (weak reflexes, unsteady gait, respiratory disorders, and tonic-clonic spasms). The dissection revealed injuries in several organs (vascularisation, bleeding, dystrophic changes). Therefore, LC50 was considered to be 7570 mg/m³, when mice were exposed to test chemical via inhalation by vapour for 2 hour exposure.
The above study is supported with another study conducted on rats for the test chemical. The acute inhalation toxicity study was conducted by using test chemical in rats at the concentration of 5000 mg/m3 inhaled as a Single dose. No mortality was observed at 5000 mg/m3. Therefore, LC50 value was considered to be >5000 mg/ m3 (>5 mg/L) when rats were exposed with test chemical by inhalation route.
Thus, based on the above summarised studies on test chemical, it can be concluded that LC50 value is >5 mg/L (>5000 mg/m3). Thus, comparing this value with the criteria of CLP regulation, the given test chemical cannot be classified for acute inhalation toxicity.
Acute Dermal Toxicity:
In different studies, the given test chemical has been investigated for acute dermal toxicity to a greater or lesser extent. Often are the studies based on in-vivo experiments in rodents, i.e. most commonly in rats and rabbits for test chemical. The studies are summarized as below –
Acute dermal toxicity test was carried out for different grades of test chemical. Groups of five male and five female rats were exposed to single doses of selected resin applied to the skin under occlusion for 24 hours. A similar group, exposed to the patches alone, served as controls. The animals were observed for 14 days following exposure for signs of toxicity. No fatalities occurred, except at the higher treatment levels with test chemical in ethanol containing 23% free phenol, during the observation period although evidence of irritancy was noted with certain grades. Body weight gain was essentially similar in treated and control animals and no significant macroscopic changes were seen in the organs at autopsy. Dermal LD50 values for all the grades examined under the conditions of exposure, considered to exceed 2000 mg/kg. Hence, The LD50 value was considered to be >2000mg/kg bw, when rats were treated with test chemical by dermal application.
The above study is supported with another study conducted on rabbits for the test chemical. The acute dermal toxicity test was conducted on rabbit to evaluate the lethal dose of test chemical .The New Zealand albino rabbits were dosed dermally with dose concentration of 3160, 5010 and 7940 mg/kg to 4 male and female rats for 14 days. Body weight, mortality, clinical signs and gross pathology changes were observed. Mortality was seen in two days. Weight loss in survivors, increasing, collapse and death occurred in the animals during study period. In gross pathology, Hemorrhagic areas of the lungs, discoloration of liver, kidneys and spleen, enlarged gall bladder, and gastrointestinal inflammation observed. No mortality was observed at dose 5010 mg/kg. Hence, Based on mortality, LD50 value was considered to be >5010 mg/kg. When rabbits were treated with test chemical by dermal application.
These studies are supported with the study mentioned in database for the test chemical.In acute dermal toxicity study, male and female new Zealand white rabbits were treated with test chemical in the concentration of 3160, 5010 and 7940 mg/kg bw by dermal application. No mortality was observed in treated rabbits at dose 3160 and 5010 mg/kg bw. Clinical signs like gastrointestinal peritonitis; behavioural food intake and somnolence (general depressed activity)(2 -3 days in survivors);increasing weakness, collapse and death were observed. Lungs and liver hypermia, kidney discoloration and gastrointestinal inflammation were observed in gross pathological observations. Therefore, LD50 value was considered to be >5010 mg/kg bw, when rabbits were treated with test chemical by dermal application.
All the above studies are further supported with the study mentioned in database for the test chemical. The acute dermal toxicity study of test chemical was conducted on rabbits at the dose concentration of 5010 mg/kg bw and 7940 mg/kg bw. The test chemical was administered dermally as a 40% suspension in corn oil. All animals were maintained under close observation for recording toxic signs and time of death .Clinical signs like reduced appetite was observed. No mortality was observed at a dose of 5010 and 7940 mg/kg bw. Therefore, LD50 value was considered to be >7940 mg/kg bw, when rabbits were treated with test chemical via dermal application.
Thus, based on the above summarised studies on test chemical, it can be concluded that LD50 value is >2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, the given test chemical cannot be classified for acute dermal toxicity.
Justification for classification or non-classification
Based on the above studies on test chemical, it can be concluded that LD50 value is >2000 mg/kg bw, for acute oral and acute dermal toxicity; and LC50 value is >5 mg/L (>5000 mg/m3), for acute inhalation toxicity. Thus, comparing these values with the criteria of CLP regulation, the given test chemical cannot be classified for acute oral, acute inhalation and acute dermal toxicity.
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