Registration Dossier
Registration Dossier
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EC number: 402-580-4 | CAS number: 111439-76-0 ALKYLSILANE TZ 01748; DYNASYLAN 9405; EURENOR(R) 5020; PSX 5305
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The result of an Ames Test (OECD Guideline 471) with the test substance was negative with and without metabolic activation.
A negative result (with and without metabolic activation) was obtained in the in vitro mammalian chromosome aberration study (OECD Guideline 473).
In addition, the test substance was not mutagenic (with and without metabolic activation) in the mouse lymphoma L5178Y test system (OECD Guideline 476).
Justification for selection of genetic toxicity endpoint
No one study is selected as there are three in vitro studies available, which all provided negative results.
Short description of key information:
The test substance was evaluated using three in vitro genetic toxicity studies; the results of all 3 studies were negative.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The above studies have all been ranked reliability 1 according to the Klimisch et al system. This ranking was deemed appropriate because the studies were conducted to GLP and in compliance with agreed protocols. Sufficient dose ranges and numbers are detailed; hence it is appropriate for use based on reliability and animal welfare grounds.
The above results triggered no classification under the Dangerous Substance Directive (67/548/EEC) and the CLP Regulation (EC No 1272/2008). No classification for genetic toxicity is therefore required.
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