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EC number: 304-835-4 | CAS number: 94279-90-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
in vivo skin irritation, test 1984, NZW rabbit on the substance 1: not skin irritant
in vitro skin irritation on FLL sample 3, sample 4 and sample 6, OECD 431: not skin irritant
in vitro eye irritation on FLL sample 3, 4 and 6: not irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Read across from an old study, no guideline followed.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: 67/548 CEE
- Deviations:
- no
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: iron stainless steel cage model 1472 "tecniplast"
- Diet: pellet, ad libitum
- Water: municipal filtered water, ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 1°C
- Humidity (%): 55 ± 15%
- Air changes (per hr): 8 per hour
- Photoperiod (hrs dark / hrs light):
IN-LIFE DATES: From: To: - Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 g - Duration of treatment / exposure:
- one application/ 4 hours
- Observation period:
- 24, 48, 72 hours , 5, and 7 days
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: ~ 10 cm^2
- % coverage:
- Type of wrap if used: multiple foil surgical gauze (2.5 X 2.5 cm). The gauze is fixed by ipoallergenic adhesive bandage (Blenderm BM). The entire animal's trunk is protected by elastic bandage (Acrylastic Beyersdorf)
REMOVAL OF TEST SUBSTANCE
- Washing (if done):
- Time after start of exposure:
SCORING SYSTEM: according to OECD guideline 404
Erithema, Edema - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- ca. 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- ca. 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal:
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Remarks:
- at the time of testing no readings at 24, 48 and 72h were required by the guidelines
- Irritation parameter:
- edema score
- Basis:
- animal:
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Remarks:
- at the time of testing no readings at 24, 48 and 72h were required by the guidelines
- Interpretation of results:
- other: not irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Based on results the product Castor oil doesn't present any signs of irritation.
- Executive summary:
Castor oil is tested by Decree 29/7/1983 67/548/CEE .Test item is applied on skin of six Newzeland albino rabbit. Based on results the product Castor oil don't present any signs of irritation.
Reference
erithema | check | 1 | 2 | 3 | 4 | 5 | 6 | mean |
24h | 1 | 2 | 2 | 1 | 2 | 2 | 1.66 | |
48h | 1 | 2 | 2 | 1 | 2 | 2 | 1.66 | |
72h | 1 | 1 | 2 | 1 | 1 | 2 | 1.33 | |
5d | 0 | 1 | 1 | 1 | 1 | 1 | 0.83 | |
7d | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
erithema | check | 1 | 2 | 3 | 4 | 5 | 6 | mean |
24h | 1 | 1 | 0 | 1 | 1 | 0 | 0.66 | |
48h | 1 | 1 | 0 | 1 | 1 | 0 | 0.66 | |
72h | 1 | 0 | 0 | 0 | 1 | 0 | 0.33 | |
5d | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
7d | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
The substance is not considered irritant or corrosive to skin and eye according to the criteria set out in the Regulation EC 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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