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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
April 20, 2018 - May 03, 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
no
Type of method:
flask method
Key result
Water solubility:
358 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
500 g/L
Temp.:
20 °C
pH:
4.2

Preliminary test

In a stepwise procedure, increasing volumes of demineralized water were added at room temperature to a defined amount of the test item. After each addition of an amount of water the mixture was treated with ultrasound for 10 minutes and visually checked for any undissolved particles.


 

Table4: Results of the preliminary test

Amount of test item

/ mg

Added volume of demineralized water / mL

Total volume of demineralized water / mL

Appearance of mixture

101.0

0.1

0.1

not dissolved

0.4

0.5

not dissolved

0.5

1.0

dissolved

The preliminary test showed that the water solubility of the test item is > 10 mg/L. According to the preliminary test the water solubility was determined by the flask method in the main test.

Flask method

The flask method was performed as described above. The data for the evaluation are given in Table5. After the equilibration time precipitate was observed in the flasks of the experiments excluding in the blank experiment.The water solubility was calculated from the measured and unrounded concentration values and not from the rounded values given in Table5.

Table5: Water solubility experiments of the test item

Experiment

24 h experiment

48 h experiment

72 h experiment

Blank

experiment (72 h)

Amount of test item / g

5.01

5.12

5.09

--

Amount of demineralized water / mL

10

10

10

10

Stirring time at 30 °C / h

24

48

72

72

pH at 22 °C

4.2

4.2

4.2

7.6

Aliquots of the flasks / mg

122

108

111

-

Aliquots of the flasks / mL

0.11

0.10

0.10

-

1st Dilution / mL

19.89

20.53

19.89

-

Aliquot of the flasks / mL

0.1

0.1

0.1

-

2nd Dilution / mL

20

20

20

-

Dilution factor

35 453

41 462

39 095

-

Measured concentration / mg/L

9.88 / 9.89

8.73 / 8.74

9.21 / 9.22

-- / --

Mean concentration / mg/L

9.88

8.73

9.21

--

Water solubility / g/L

350

362

360

--

The water solubility of the test item at 20 °C was determined to be 358 g/L (± 6 g/L).

Executive summary:

The water solubility cS of the test item at a temperature of 20 °C was determined according to the flask method. It was found to be without correction of the purity:

                                                                 cS = 358 g/L (± 6 g/L)

Description of key information

The water solubility cS of the test item at a temperature of 20 °C was determined according to the flask method. It was found to be without correction of the purity:

                                                                 cS = 358 g/L (± 6 g/L)

Key value for chemical safety assessment

Water solubility:
358 g/L
at the temperature of:
20 °C

Additional information