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Diss Factsheets
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EC number: 301-037-8 | CAS number: 93980-59-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data based on the inhibition control of a ready biodegradability study. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2012).
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
Toxicity control: In one test vessel, 30 mg of the test sample and 30 mg of sodium benzoate were accurately weighed with an electronic analytical balance and added to the mineral medium [the volume
subtracting the volume (4.00 mL) of activated sludge from 300 mL], so that each concentration of the test item and sodium benzoate reaches 100 mg/L. - Test organisms (species):
- activated sludge, domestic
- Details on inoculum:
- - Source of inoculum/activated sludge: Activated sludge obtained from site Kurume central sewage treatment center (Kurume-shi, Fukuoka, Japan), receiving predominantly domestic sewage
- Concentration of sludge: 30 mg/L (suspended solids) - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 14 d
- Details on test conditions:
- TEST CONDITIONS
- Composition of medium: mineral medium according to guidelne
- Test temperature: 22±1 °C
- Continuous darkness: yes
- pH: 7.3 - 7.8 (at the end of exposure)
- Other: Test solutions were stirred continuously.
TEST SYSTEM
- Culturing apparatus: Closed system oxygen consumption measuring apparatus (No. CM-067)
- Number of culture flasks/concentration: 2
- Details of trap for CO2 and volatile organics if used: Soda lime No.1 (for absorption of carbon dioxide, Wako Pure Chemical Industries)
SAMPLING
- Sampling frequency: O2 consumption was measured continuously.
- Sampling method: automatic measurement without specific sampling - Reference substance (positive control):
- yes
- Remarks:
- benzoic acid, sodium salt
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Result of toxicity control from ready biodegradability test
- Results with reference substance (positive control):
- The reference material (sodium benzoate) attained 99% degradation after 14 days
Reference
The toxicity control attained 34% degradation after 14 days of incubation.
“If in a toxicity test, containing both the test and reference substance, less than 35% degradation (based on total DOC) or less than 25% (based on total ThOD or ThCO2) occurred within 14 days, the test substance can be assumed to be inhibitory.”(OECD guideline 301)
Since more than 25% degradation occurred in the toxicity control, the substance is with high probability not toxic to aquatic microorganisms. The test item concentration in the toxicity control of 100 mg/L can be used as NOEC value for the toxicity to aquatic microorganisms.
Description of key information
NOEC (14 d): 100 mg/L (inhibition control, OECD 301F)
Key value for chemical safety assessment
Additional information
Experimental studies investigating the toxicity of the substance to aquatic microorganisms are not available. Therefore, the inhibition control of the available study on ready biodegradability was used to assess the toxicity to microorganisms. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2017). Substances can be assessed as not inhibitory to aquatic microorganisms, if a biodegradation rate of > 25% based on oxygen demand (BOD/ThOD) is reached within 14 days in the inhibition control of a ready biodegradation test (OECD guideline 301). In the available ready biodegradation test on Sorbitan tridocosanoate, following OECD guideline 301F, the inhibition control contained 100 mg/L of the test sample and of sodium benzoate, respectively. A degradation rate of 34% based on O2 consumption was determined after 14 days of incubation. The reported results indicate no inhibitory effects of the substance on aquatic microorganisms and the test item concentration of 100 mg/L is used as NOEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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