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EC number: 269-085-1 | CAS number: 68187-30-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP guideline study with no information on the inoculum. No information if all validity criteria were fulfilled.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- - - Source of inoculum/activated sludge: not specified
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 5 - 40 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Composition of medium: anorganic nutrient solution containing micronutrients and essential vitamines
- Test temperature: 20 - 25 °C
- Continuous darkness: yes
TEST SYSTEM
- Other: The test solution was placed on a mechanical shaker
SAMPLING
- Sampling frequency: Samples were taken after 7, 14, 21, 27 and 28 days.
CONTROL AND BLANK SYSTEM
- Inoculum blank: Yes, a trial without the test or reference substance was conducted - Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (DOC removal)
- Value:
- 94.4
- Sampling time:
- 28 d
- Details on results:
- The test substance reached a biodegradation of 94.4% within a test period of 28 days. The 10 day-window was met. Thus, the test substance is readily biodegradable according to OECD criteria.
- Results with reference substance:
- The reference substance was biodegraded to 97.9% within 28 days.
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- readily biodegradable
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reason / purpose for cross-reference:
- read-across source
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 94.4
- Sampling time:
- 28 d
Referenceopen allclose all
Table 1: Biodegradation of reference and test substance in % DOC removal throughout the test period of 28 days
Days |
Reference substance |
Test substance |
7 |
93.0 |
81.4 |
14 |
97.8 |
90.5 |
21 |
97.2 |
93.0 |
27 |
97.8 |
95.5 |
28 |
97.9 |
94.4 |
Description of key information
Readily biodegradable: 94.4% in 28 days (OECD 301E, read across)
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
No studies investigating the ready biodegradability of l-Glutamic acid, N-coco acyl derivs., disodium salts (CAS No. 68187-30-4) are available. Thus, available data for the source substance l-Glutamic acid, N-coco acyl derivs., monosodium salts (CAS No. 68187-32-6) was used in a read-across approach. The read across is considered valid as both substances are structurally identical (solely differing in the degree of deprotonation being di- and monosodium salts, respectively), which assume very similar physico-chemical properties resulting in identical environmental behavior and ecotoxicity.
The read-across key study was performed according to OECD guideline 301E using polyvalent microorganisms as inoculum (Hoechst, 1989). Test substance concentrations of 4 – 50 mg DOC/L were tested. The test substance showed a biodegradation of 81.4% after 7 days and 94.4% after an incubation period of 28 days. Thus, the test substance is readily biodegradable according to OECD criteria. Due to the very high structural similarity, this result can also be considered for l-Glutamic acid, N-coco acyl derivs., disodium salts (CAS No. 68187-30-4).
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