Registration Dossier
Registration Dossier
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EC number: 264-119-1 | CAS number: 63393-93-1
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC = 13.1 mg/L for activated sludge (toxicity control OECD 301 B)
Key value for chemical safety assessment
Additional information
Since no studies on the toxicity to aquatic microorganisms are available a ready biodegradability study is used to derive a NOEC for the toxicity to aquatic microorganisms. If a compound degrades well in a ready biodegradability test, or does not inhibit the degradation of a positive control at a certain concentration, this concentration can be used as a NOEC value. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2008).
A substance can be assumed not to be inhibitory to aquatic microorganisms, if in the toxicity control of a ready biodegradation test, more than 25% degradation based on CO2 evolution (CO2/ThCO2) occurred within 14 days (OECD guideline 301). For Fatty acids, lanolin, isopropyl esters (CAS No. 63393-93-1) a biodegradation test according to OECD guideline 301 B is available (Clarke, 2012). The test includes a toxicity control, which contains 13.1 mg/L of Fatty acids, lanolin, isopropyl esters and 17.1 mg/L of the reference material sodium benzoate. The toxicity control attained 50% degradation after 14 days of incubation. Hence, the substance is not toxic to aquatic microorganisms in the toxicity control and the test item concentration of 13.1 mg/L can be used as NOEC.
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