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EC number: 262-110-7 | CAS number: 60223-95-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Groups of rats (5/sex/dose) received a single dose of the test substance at 2000, 3000, 4000, 4500 and 5000 mg/kg bw (PSL 1978). In all groups mortality was reported. Necropsy showed degeneration and necrosis of the stomach as well as liver discoloration in several dead rats. The LD50 is 2035 mg/kg bw.
In a very limited reported inhalation study the LD50 found in rats was > 110 mg/L (PSL 1978)
Rabbits (5/sex) were dermally exposed to the test substance for 24 hours (PSL 1977). No effects other than slight erythema and well defined oedema (not observed after day 9) were reported. Body weight gain was considered normal. Necropsy did not reveal any findings. The LD50 is > 1100 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: non GLP study with limited information on test design and results. The study allows a conclusion on the height of the LD50. The information in the report is limited to the information in the summary.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- method seems similar to OECD 401
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200-300 g
- Fasting period before study: 18 hours
- Housing: individually
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data:
- Photoperiod (hrs dark / hrs light): no data - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 5 mL/kg bw
- Doses:
- 2000, 3000, 4000, 4500 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 males + 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no, only on decendents
- Other examinations performed: clinical signs - Statistics:
- Litchfield-Wilcoxin Probit Analysis
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 700 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 3 080 - <= 4 440
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 035 mg/kg bw
- Based on:
- act. ingr.
- 95% CL:
- >= 1 694 - <= 2 442
- Mortality:
- 1 male + 1 female at 2000 mg/kg bw
2 males + 1 female at 3000 mg/kg bw
2 males + 3 females at 4000 mg/kg bw
1 male + 5 females at 4500 mg/kg bw
4 males + 4 females at 5000 mg/kg bw - Clinical signs:
- none
- Body weight:
- no data
- Gross pathology:
- degeneration and necrosis of the stomach; liver discoloration in several dead rats
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- tance is 2035 mg/kg bw
- Executive summary:
Groups of rats (5/sex/dose) received a single dose of the test substance at 2000, 3000, 4000, 4500 and 5000 mg/kg bw. In all groups mortality was reported. Necropsy showed degeneration and necrosis of the stomach as well as liver discoloration in several dead rats. The LD50 is 2035 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 035 mg/kg bw
- Quality of whole database:
- test on formulation
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1978
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Limited study report (non-GLP), exposure for 1 hour, very limited data on test conditions. The information in the report is limited to the information in the summary.
- Qualifier:
- according to guideline
- Guideline:
- other: FHSLA, CFR, Title.21, para. 191.10
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: males: 240-290 g; females 219-250 g
- Housing: 5 animals/ cage
- Diet/ water: no data
ENVIRONMENTAL CONDITIONS: no data - Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION: spray was introduced into the chamber via a nebulizer, was circulated and was directed away from the animals.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 1 h
- Concentrations:
- 200 mg/L (nominal)
- No. of animals per sex per dose:
- 5 males + 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not indicated
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- NA
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 200 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 110 mg/L air (nominal)
- Based on:
- act. ingr.
- Exp. duration:
- 1 h
- Mortality:
- none
- Clinical signs:
- other: none reported
- Body weight:
- no data
- Gross pathology:
- no findings
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The 1-h LC50 of the test substance is > 110 mg/L
- Executive summary:
Rats (5/sex) were exposed to an aerosol of 110 mg/L of the test substance for one hour. No mortality occurred during the 14 -day observation period. No effects on clinical behaviour or findings at necropsy. Therefore the LC50 is > 110 mg/L
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- test on formulation
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study similar to the guideline (OECD 402), but non-GLP and with limited information on the conditions of performance. The information in the report is limited to the information in the summary.
- Qualifier:
- according to guideline
- Guideline:
- other: Federal Hazardous Sub stances Act (1973)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data (from stock)
- Age at study initiation: mature
- Weight at study initiation:2045-2810 g
- Housing: individually
- Diet: Purina Rabbit Chow ad libitum
- Water: ad libitum
- Acclimation period: not indicated
ENVIRONMENTAL CONDITIONS: no data - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: not indicated
- Type of wrap if used: occlusive, rubber dam
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 mL
- Concentration (if solution): 55% - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 males + 5 females
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily; weighing at start and on day 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and body weight - Statistics:
- NA
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 100 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- none
- Clinical signs:
- slight erythema and well defined oedema until day 9, thereafter no findings
- Body weight:
- bodyweight gain within expected ranges
- Gross pathology:
- no findings
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of the test substance is > 1100 mg/kg bw
- Executive summary:
Rabbits (5/sex) were dermally exposed to the test substance for 24 hours. No effects other than slight erythema and well defined oedema (not observed after day 9) were reported. Body weight gain was considered normal. Necropsy did not reveal any findings. The LD50 is > 1100 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 100 mg/kg bw
- Quality of whole database:
- test on formulation
Additional information
All studies are performed on formulations. This lowers the reliability. The results are however indicative for a low acute toxicity via the oral, dermal and inhalation route. The main effects reported are related to local irritation.
Justification for selection of acute toxicity – oral endpoint
Study similar to the guideline. The doses tested ranged from 2000-5000 mg/kg bw. The LD50 value is corrected for purity.
Justification for selection of acute toxicity – inhalation endpoint
the study is indicative for low toxicity.
Justification for selection of acute toxicity – dermal endpoint
Study similar to the guideline. Limit test with formulation at 2000 mg/kg bw. The LD50 value is corrected for purity.
Justification for classification or non-classification
Based on findings in acute oral, dermal and inhalation studies with the substance it can be concluded that no classification for acute toxicity by oral, dermal or inhalation route is required according to CLP (Regulation EC No 1272/2008). Given the fact that the substance is not a pure hydrocarbon, classification for aspiration hazards is not required. No specific target organ toxicity was observed in any of the acute studies and thus STOT single exposure classification is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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