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EC number: 257-407-3 | CAS number: 51772-85-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Toxicity to algae based on weight of evidence: 72 hour ErC50 >100 mg/l; NOEC(growth) ≥100 mg/l (nominal) (highest concentration tested) (EU method C.3), and 72 hour ErC50 >536 mg/l; ErC10 503 mg/l (nominal) (EU method C.3), both read-across from a structurally related substance, 3-trimethoxysilylpropyl methacrylate (CAS 2530-85-0). The ErC50 values are equivalent to >83 mg/l and >445 mg/l when expressed in terms of the silanol hydrolysis product. The quantified results from the second test are taken as the basis of PNEC, as these are the lowest results that are not limit values.
Key value for chemical safety assessment
Additional information
There are no reliable algal toxicity data available for 3-[tris(acetoxy)silyl]propyl methacrylate (CAS 51772-85-1), therefore good quality data for the structurally-related substance, 3-trimethoxysilylpropyl methacrylate (CAS 2530-85-0), have been read across. Both substances share the same silanol hydrolysis product, 3-(trihydroxysilyl)propyl methacrylate. The other hydrolysis products are acetic acid and methanol, respectively.
A 72 hour ErC50 value of >100 mg/l and NOEC(growth rate) of ≥100 mg/l (nominal) (highest concentration tested) have been determined for the effects of the structurally-related substance, 3-trimethoxysilylpropyl methacrylate (CAS 2530-85-0) on growth rate of Scenedesmus subspicatus (new name: Desmodesmus subspicatus) (RCC, 2002c). Test media were prepared by direct addition with stirring for 35 minutes. However in view of the exposure regime it is likely that the test organisms were primarily exposed to the hydrolysis products of the substance. The results may be expressed in terms of concentration of the hydrolysis product, 3-(trihydroxysilyl)propyl methacrylate, by applying a molecular weight correction: (MW of silanol = 206.27 / MW of parent = 248.35) * 100 mg/l = 83 mg/l.
In a second reliable test also using 3-trimethoxysilylpropyl methacrylate (CAS 2530-85-0), a 72 hour ErC50 value of >536 mg/l and ErC10 of 503 mg/l were determined for effects on growth rate of Scenedesmus subspicatus (new name: Desmodesmus subspicatus) (Infracor, 2000). A NOEC(cell number) of 322 mg/L was established in this test. In this test, the registration substance would have been fully hydrolysed during preparation of stock solution (which was also filtered prior to the exposure period). There is potential for oligomerisation to have occurred during preparation of the stock, however, high recoveries at the end of the test indicate that precipitation did not occur to a significant extent. At the loading levels corresponding to the NOEC and EC50 the concentration of monomeric silanol should have been stable in the test medium. The results may be expressed in terms of concentration of the hydrolysis product, 3-(trihydroxysilyl)propyl methacrylate, by applying a molecular weight correction: (MW of silanol = 206.27 / MW of parent = 248.35) * 536 mg/l = 445 mg/l.
The 2002 study did not observe any effects up to 100 mg/l loading but the 2000 study did observe effects in the same species at higher loading levels. It is therefore appropriate to derive an indicative PNEC for the silanol hydrolysis product from the second study result for use in chemical safety assessment. Both of these reliable studies provide useful weight of evidence for the hazard assessment.
Refer to the discussion in the Section 6 endpoint summary (Section 7.0 of CSR) for further discussion of the approach to chemical safety assessment for this registration substance, and justification for read-across used.
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