Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 255-464-9 | CAS number: 41621-49-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Data published on toxicity studies to aquatic invertebrates for 2-aminoethanol, neutral form of ethanolaminium cation.
- GLP compliance:
- not specified
- Remarks:
- Data published. No detailed information about GLP compliance.
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 32.6 mg/L
- Conclusions:
- In water at environmentally relevant pH, 2-aminoethanol will exist as ethanolaminium cation. For 2-aminoethanol, the neutral form of ethanolaminium cation, the lowest reliable short-term toxicity value to Daphnia Magna is EC50 (48h) = 32.6 mg/L (measured; pH = 7.3-9.1).
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- 1. SOFTWARE
ECOSAR v1.11 model (US EPA, July 2012)
2. MODEL (incl. version number)
ECOSAR v1.11 model
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
O=C(N(O)C(=CC=1C)C(CCCC2)C2)C1
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
See METHODOLOGY DOCUMENT for the ECOlogical Structure-Activity Relationship Model (ECOSAR)(US EPA)
5. APPLICABILITY DOMAIN
In the development of the ECOSAR equations for neutral organics and classes with excess toxicity, the training sets generally include chemicals with log Kow values in the range of -3 to 8 and molecular weights less than 1000. However, the domain of the model is considered to be larger than the descriptor range of the training set of chemicals.It has been determined through empirical data that for acute toxicity endpoints, chemicals with a log Kow value >5.0 are generally expected to have no effects at saturation
6. ADEQUACY OF THE RESULT
The estimate value has been generated by a valid model. The model is applicable to Ciclopirox with the necessary level of reliability and is sufficiently relevant for the regulatory purpose. - Principles of method if other than guideline:
- Software tool(s) used including version: ECOSAR v1.11 model (US EPA, July 2012).
Model(s) used: ECOSAR v1.11 model (US EPA, July 2012).
Model description: see field 'Justification for for type of information'
Justification of QSAR prediction: see field 'Justification for type of information' - Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 16.34 mg/L
- Conclusions:
- Within the environmentally relevant pH range, a substantial fraction of 6-cyclohexyl-4-methyl-2-oxopyridin-2(1H)-olate anion will be in the neutral form (6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one (Ciclopirox); CAS 29342-05-0; pKa (estimated) =6.84 (ChemAxon)).
EC50 (aquatic invertebrates-48h) for Ciclopirox is estimated to be 16.34 mg/l.
Referenceopen allclose all
Description of key information
Since Ciclopirox olamine is an organic salt, it is expected to dissociate upon its release in the environment and to dissolve in water into 6-cyclohexyl-4-methyl-2-oxopyridin-2(1H)-olate anoin and ethanolaminium cation. Because of this dissociation behaviour, the assessment of Ciclopirox olamine toxicity to aquatic invertebrates was focused on dissociation products.
For 2-aminoethanol, the neutral form of ethanolaminium cation, the lowest reliable short-term toxicity value to Daphnia Magna is EC50 (48h) = 32.6 mg/L (measured; pH = 7.3-9.1). In water at environmentally relevant pH, 2-aminoethanol will exist as ethanolaminium cation.
Within the environmentally relevant pH range, a substantial fraction of 6-cyclohexyl-4-methyl-2-oxopyridin-2(1H)-olate anion will be in the neutral form (6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one (Ciclopirox); CAS 29342-05-0; pKa (estimated) =6.84 (ChemAxon)).
For Ciclopirox no experimental data on short-term toxicity to aquatic invertebrates have been identified. Acute toxicity to aquatic invertebrates of Ciclopirox was primarily examined using ECOSAR v1.11 model (US EPA, July 2012).
ECOSAR v1.11 Results for Ciclopirox: 48-h LC50 for Daphnid: 16.34 mg/L.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.