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Diss Factsheets
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EC number: 252-038-4 | CAS number: 34452-51-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Based on an EC3 of 16.5%, KTG is a moderate skin sensitiser (Skin Sens 1B).
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003-06-02 - 2003-10-08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Dept. of Health, UK
- Type of study:
- mouse local lymph node assay (LLNA)
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Vehicle:
- propylene glycol
- Concentration:
- The test substance was initially applied as 0.25%, 0.5% or 1.0% w/v preparation in propylene glycol. Further groups of animals were subsequently doses with 2.5%, 5%, 10%,25% or 50% w/v preparations in propylene glycol.
- No. of animals per dose:
- 4
- Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
- Positive control results:
- Hexylcinnamaldehyde was shown to be a skin sensitiser, confirming the validity of the protocol used for the study.
- Key result
- Parameter:
- EC3
- Value:
- 16.5
- Test group / Remarks:
- linear interpolation between 10% and 50%
- Parameter:
- SI
- Value:
- 1.58
- Test group / Remarks:
- 10%
- Parameter:
- SI
- Value:
- 4.83
- Test group / Remarks:
- 25%
- Parameter:
- SI
- Value:
- 12.04
- Test group / Remarks:
- 50%
- Interpretation of results:
- Category 1B (indication of skin sensitising potential) based on GHS criteria
- Conclusions:
- Based on an EC3 of 16.5%, KTG is a moderate skin sensitiser (Skin Sens 1B).
- Executive summary:
A sample of KTG 43% was assessed for its skin sensitisation potential using the mouse Local Lymph Node Assay. The assay determines the level of T lymphocyte proliferation in the lymph nodes draining the site of chemical application, by measuring the amount of radiolabelled thymidine incorporated into the dividing cells.
Concentration of test substance (% w/v)
Number of lymph nodes assayed
Disintegrations per minute (dpm)
dpm per lymph node
Test control ratio
0 (vehicle only)
8
1896
2.37
N/A
0.25
8
4315
5.39
2.27
0.5
8
3675
4.59
1.94
1.0
8
2445
6.06
1.29
0 (vehicle only)
8
4362
5.45
N/A
2.5
8
4659
5.82
1.07
5
8
5443
6.80
1.25
10
8
6868
8.59
1.58
0 (vehicle only)
8
4468
5.59
N/A
25
8
21601
27.00
4.83
50
8
53827
67.28
12.04
N/A: not applicable
The test substance was shown to have the capacity to cause skin sensitisation when applied as a 30% w/v preparation in propylene glycol. In conclusion, KTG is a skin sensitiser.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Experiences in humans confirmed the sensitizing potential of thioglycolates in general.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on sufficient animal and human data KTG can be classified as:
Skin Sens. 1B. H317. May cause an allergic skin reaction.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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