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Diss Factsheets
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EC number: 250-284-7 | CAS number: 30674-80-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-Guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Ministerium für Arbeit, Integration und Soziales des Landes Nordrhein-Westfalen, Düsseldorf, Germany
- Analytical monitoring:
- no
- Details on sampling:
- - Concentrations: 20 mg DOC/L test item + 20 mg DOL/L reference item
- Sampling method: CO2 was trapped in sodium hydroxide and measured as inorbanic carbon. On the days of CO2 measurement, the sodium hydroxide absorbers were disconnected and aliquots of the solutions were measured regarding the TIC concentration. New absorbers (each containg 200 mL fresh 0.05 M sodium hydroxide) were connected to the test vessel.
On the 28th day 1 mL of concentrated hydrochloric acid was added to each test vessel. Subsequently, they were aerated overnight to drive off the carbon dioxide present in the test suspension. On day 29 the last analysis of evolved carbon dioxide was done. Additionally, the biodegradation was measured by determining the DOC in samples of suspension taken at start and 28 d after addition of the test item. The samples at day 28 were taken before the concentrated hydrochloric acid was added. - Vehicle:
- no
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- - Preparation of inoculum for exposure: The sludge was washed in mineral medium and centrifuged (at 1100 g for 10 minutes). The supernatant was discarded. The concentrated sludge was suspended in mineral medium to a concentration of 1 - 3 g suspended solids/L. The sludge was aerated with CO2-free air over night to purge the system of carbon dioxide. A sample was withdrawn just before use for the determination of the dry weight of the suspended solids.
- Initial biomass concentration: The concentration of activated sludge used in the test was 29 mg dry mass/litre (87 mg dry mass/3 L). - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 28 d
- Test temperature:
- 20 ± 2 °C
- pH:
- 7.4
- Nominal and measured concentrations:
- 20 mg DOC/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 5-litre flasks containing 2400 mL mineral medium
OTHER TEST CONDITIONS
- Photoperiod: Darkness - Reference substance (positive control):
- no
- Duration:
- 28 d
- Dose descriptor:
- EC50
- Effect conc.:
- > 20 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: DOC
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
Reference
Description of key information
No effects on microorgansims
Key value for chemical safety assessment
Additional information
Toxicity of 2 -isocyanatoethyl-methacrylate (MOI) on microorganisms was assessed on the basis of a toxic control tested in the biodegradation study conducted by Simon (2012). This test was performed according to OECD Guideline 301B and EU Method C.4 -C under GLP conditions. In this toxic control, test substance and reference substance were incubated in activated sludge at a concentration of approximately 20 mg/L DOC, respectively, at 22 ± 2 °C. At the end of the test, the biodegradation was 100%, indicating that MOI has no inhibitory effect on the activity of the sludge microorganisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.