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Diss Factsheets
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EC number: 236-412-4 | CAS number: 13360-57-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity
- Remarks:
- subcutaneous
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dimethylsulphamoyl chloride
- EC Number:
- 236-412-4
- EC Name:
- Dimethylsulphamoyl chloride
- Cas Number:
- 13360-57-1
- Molecular formula:
- C2H6ClNO2S
- IUPAC Name:
- N,N-dimethylsulfamoyl chloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- peanut oil
- Analytical verification of doses or concentrations:
- no
- Post exposure period:
- until natural death, moribound animals were sacrificed.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Basis:
nominal conc.
- No. of animals per sex per dose:
- 25 male and 25 female animals per dose.
10 and 100 mg/kg bw - Control animals:
- yes, concurrent vehicle
Results and discussion
Any other information on results incl. tables
No differences in state and behaviour between treated and control animals.
No differences in body weight development between treated and control animals.
Survival time in treated animals significantly and dose related shortend in treated animals.
Tumors - fibrosarcoma - at the treatment site were developed in a higher rate and earlier as in control animals:
10 mg/kg : male 22 treated vs. 4 control
female 11 treated vs. 1 control of 25 each
100 mg/kg: male 22 treated vs. 4 control
female 17 treated vs. 1 control of 25 each
Appearance of the tumors from week 30 on in treated animals vs. week 95 in control animals.
Number and distribution of other malign and benign tumors did not show a treatment related increase.
Applicant's summary and conclusion
- Conclusions:
- A clear local cancerogenic effect at the application site at higher dosage.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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