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EC number: 233-108-3 | CAS number: 10034-81-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
acute tox (oral) LD50 = 1490 mg/kg b.w. (prediction by OECD QSAR Toolbox v4.3.1, 2019; based on experimental results of closely related analogues Potassium perchlorate and Lithium perchlorate)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Remarks:
- in silico, (Q)SAR performed with OECD QSAR Toolbox, Read Across analysis
- Type of information:
- other: (Q)SAR from supporting substances (structural analogues or surrogates) for which an experimental result is available
- Adequacy of study:
- key study
- Study period:
- 2019-03-29
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification, with an experimental result (as provided by the OECD QSAR Toolbox)
- Justification for type of information:
- 1. SOFTWARE
OECD QSAR Toolbox v4.3.1
2. MODEL (incl. version number)
Read Across analysis
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
[Mg+2].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
Please refer to 'Attached justification'
5. APPLICABILITY DOMAIN
Please refer to 'Attached justification' - Guideline:
- other: ECHA Guidance R.6
- Principles of method if other than guideline:
- - Software tool(s) used including version: OECD QSAR Toolbox v4.3.1
- Model(s) used: Read Across analysis
- Model description: see field 'Justification for non-standard information' and 'Attached justification'
- Justification of QSAR prediction: see field 'Justification for type of information' and 'Attached justification' - GLP compliance:
- no
- Remarks:
- Not applicable (QSAR calculation)
- Specific details on test material used for the study:
- [Mg+2].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O
- Species:
- other: rodent
- Route of administration:
- oral: unspecified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 490 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral toxicity of Magnesium perchlorate to rodents was predicted with OECD QSAR Toolbox v4.3.1 using experimental results of the analogues Potassium Potassium perchlorate (CAS 7778-74-7) and Lithium perchlorate (CAS 7791-03-9). Since the perchlorate is considered to trigger the toxicity, this approach is justified. The predicted LC50 is 1490 mg/kg bw.
Predictions by the OECD QSAR Toolbox v4.3.1 with experimental result(s) of closely related perchlorate(s) with CAS 7778-74-7 and 7791-03-9 contained therein are used to address the endpoint, which is entirely appropriate to draw conclusions on the acute toxicity of Magnesium perchlorate by the oral route.
The predicted LD50 of 1490 mg/kg b.w. is above the limit value of 300 mg/kg b.w. and below the limit value of 2000 mg/kg b.w., wherefore Magnesium perchlorate needs to be classified as acute tox. 4 according to Regulation 1272/2008 and amendments. - Executive summary:
The acute oral toxicity of magnesium perchlorate to rodents was calculated with OECD QSAR Toolbox v4.3.1 by read-across analysis using the analogues potassium perchlorate and lithium perchlorate. Since the perchlorate is considered to trigger the toxicity this read-across approach is justified. The predicted LC50 is 1490 mg/kg bw.
Predictions by the OECD QSAR Toolbox v4.3.1 with experimental result(s) of closely related perchlorate(s) with CAS 7778-74-7 and 7791-03-9 contained therein are used to address the endpoint, which is entirely appropriate to draw conclusions on the acute toxicity of Magnesium perchlorate by the oral route.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 490 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The acute oral toxicity of Magnesium perchlorate to rodents was predicted with OECD QSAR Toolbox v4.3.1 using experimental results of the closely analogue substances Potassium perchlorate (CAS 7778-74-7) and Lithium perchlorate (CAS 7791-03-9). These analogue substances were tested for their acute oral toxicity to rodents according to OECD TG 423 (GLP). Since the perchlorate is considered to trigger the toxicity, this approach is justified and considered as entirely appropriate to draw conclusions on the acute toxicity of Magnesium perchlorate by the oral route. However, the registrant is prepared to conduct an experimental study but considered it as not necessary at first instance taking into account the available results.
Justification for classification or non-classification
The predicted LD50 of 1490 mg/kg b.w. is above the limit value of 300 mg/kg b.w. and below the limit value of 2000 mg/kg b.w., wherefore Magnesium perchlorate needs to be classified as acute tox. 4 according to Regulation 1272/2008 and amendments.
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