Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-051-1 | CAS number: 7784-18-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.047 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 75
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.068 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 300
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
Acute DNELs:
Worker: Production of the aluminum fluoride is in excess of 10 t/y. According to the REACh "Guidance on information requirements and chemical safety assessment, Part B: Hazard Assessment", above 10 t/y, the establishment of acute toxicity DNEL is unnecessary in most cases, as the DNEL based on long-term exposure is normally sufficient to ensure that adverse effects do not occur. Thus, as long term DNELs are available for aluminum fluoride and these substances are not classified for acute toxicity via any route of exposure, separate acute DNELs were not derived.
Long-term DNELs:
DNELs are based on the rat inhalation study (key study selected) entitled "Sub-acute (28-day) inhalation toxicity study with aluminium trifluoride in rats¿. The most sensitive endpoint was selected as repeated dose toxicity. It should be noted that a 5-month inhalational study was available, and would provide a more conservative DNEL value; however this study was not used for DNEL derivation due to deficiencies in the study design. The 5-month inhalational study focused on effects on the lung and brain, and other possible indicators of toxicity (e.g., clinical chemistry, histopathology of other tissues) were not evaluated.
Starting Dose for DNEL calculation:
7 mg/m3(based on NOAEL)
Modified dose for DNEL Calculation
Worker ¿ Inhalation = 7 mg/m3x 6/8 x 6.7/10 = 3.52 mg/m3(no adjustment for absorption)
Worker ¿ Dermal =7 mg/m3x 0.29 m3/kg bw x 1/0.1 = 20.3 mg/kg bw [an adjustment factor of 10% was used to account for Dermal absorption] .
Assessment Factors (AF) ¿
Worker ¿ Inhalation = 2.5 (for non-metabolic species differences) x 5 for (intraspecies difference); no scaling factor required (as per REACh guidance) x 6 (duration factor sub-acute to chronic)
Worker ¿ Dermal = 4 x 2.5 (species differences) x 5 for (intraspecies difference); no scaling factor required (as per REACh guidance) x 6 (duration factor sub-acute to chronic)
Aluminum fluoride is an inorganic compound and is not expected to dissolve in organic solvents. The solubility of aluminum fluoride (AlF3) was measured using flask method and was reported based on Al and F, ranging from 5.3 mg/L to 8.5 mg/L of AlF3 on the basis of F analysis and 5.4 mg/L to 9.4 mg/L of AlF3 on the basis of Al analysis (see Section 4 of this dossier; Behrens and Andersen). Based on a lack of solubility in organic solvents and in water, a 10% absorption factor was assumed. This is consistent with the dermal absorption value assumed by the ECHA Annex 1 Background document to the Opinion proposing harmonized classification and labelling at Community level of the read across substance Trisdoium hexafluroaluminate (ECHA, 2010).
Final DNELs
Worker ¿ Inhalation = 0.047 mg/m3
Worker ¿ Dermal =0.068mg/kg bw
References:
Behrens A & Andersen KJ, Solubility of AlF3. DHI Water & Environment, Agern Allé 11, DK-2970,. (2002)
European Chemicals Agency Committee for Risk Assessment RAC. Annex I Background Document to the Opinion proposing harmonized classification and labelling at Community level of Trisodium hexafluoroaluminate (Cryolite), natural and synthetic. Adopted 23 May 2010.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.008 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 150
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.024 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 600
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.002 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 600
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
Acute DNEL:
General population: Production of the aluminum fluoride is in excess of 10 t/y. According to the REACh "Guidance on information requirements and chemical safety assessment, Part B: Hazard Assessment", above 10 t/y, the establishment of acute toxicity DNEL is unnecessary in most cases, as the DNEL based on long-term exposure is normally sufficient to ensure that adverse effects do not occur. Thus, as long term DNELs are available for aluminum fluoride and these substances are not classified for acute toxicity via any route of exposure, separate acute DNELs were not derived.
Long-term DNELs:
DNELs are based on the rat inhalation study (key study selected) entitled "Sub-acute (28-day) inhalation toxicity study with aluminium trifluoride in rats¿. The most sensitive endpoint was selected as repeated dose toxicity. It should be noted that a 5-month inhalational study was available, and would provide a more conservative DNEL value; however this study was not used for DNEL derivation due to deficiencies in the study design. The 5-month inhalational study focused on effects on the lung and brain, and other possible indicators of toxicity (e.g., clinical chemistry, histopathology of other tissues) were not evaluated.
Starting Dose for DNEL calculation:
7 mg/m3(based on NOAEL)
Modified dose for DNEL Calculation
General Population ¿ Inhalation = 7 mg/m3x 6/24 x 5/7 = 1.25 mg/m3(no adjustment for absorption)
General Population ¿ Oral = 7 mg/m3x 0.29 m3/kg bw x 5/7 = 1.45 mg/kg bw (no adjustment for absorption)
General Population Dermal - 7 mg/m3x 0.29 m3/kg bw x 5/7 x 1/0.1 = 14.5 mg/kg bw (10% absorption factor)
Assessment Factors (AF) ¿
General ¿ Inhalation = 2.5 (for non-metabolic species differences) x 10 for (intraspecies difference); no scaling factor required (as per REACh guidance) x 6 (duration factor sub acute to chronic)
General Population ¿ Oral = 4 x 2.5 (species differences) x 10 for (intraspecies difference); no scaling factor required (as per REACh guidance) x 6 (duration factor sub acute to chronic)
General Population - Dermal = 4 x 2.5 (species differences) x 10 for (intraspecies difference); no scaling factor required (as per REACh guidance) x 6 (duration factor sub acute to chronic)
Absorption
Aluminum fluoride is an inorganic compound and is not expected to dissolve in organic solvents. The solubility of aluminum fluoride (AlF3) was measured using flask method and was reported based on Al and F, ranging from 5.3 mg/L to 8.5 mg/L of AlF3 on the basis of F analysis and 5.4 mg/L to 9.4 mg/L of AlF3 on the basis of Al analysis (see section 4, Behrens and Andersen). Based on a lack of solubility, a 10% absorption factor was assumed This is consistent with the dermal absorption value assumed by the ECHA Annex 1 Background document to the Opinion proposing harmonized classification and labelling at Community level of the read across substance Trisdoium hexafluroaluminate (ECHA, 2010).
Final DNELs
General Population ¿ Inhalation = 0.0083 mg/m3
General Population ¿ Oral = 0.0024 mg/kg bw
General Population - Dermal =0.024mg/kg bw
References:
Behrens A & Andersen KJ, Solubility of AlF3. DHI Water & Environment, Agern Allé 11, DK-2970,. (2002)
European Chemicals Agency Committee for Risk Assessment RAC. Annex I Background Document to the Opinion proposing harmonized classification and labelling at Community level of Trisodium hexafluoroaluminate (Cryolite), natural and synthetic. Adopted 23 May 2010.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.