Octyl laurate

Long-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

Refer to analogue justification provided in IUCLID section 13

Reason / purpose for cross-reference:

read-across source

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

>= 1 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Remarks:

(WAF)

Basis for effect:

reproduction

Duration:

21 d

Dose descriptor:

EC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Remarks:

(WAF)

Basis for effect:

reproduction

Description of key information

No toxic effects up to the limit of water solubility; read-across

Additional information

Since no studies investigating the long-term toxicity of octyl laurate (CAS 5303-24-2) to aquatic invertebrates are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance Fatty acids, C8-16, 2-ethylhexyl esters (CAS 135800-37-2) was conducted. The source substance is considered to be representative to evaluate the long-term toxicity of octyl laurate to aquatic invertebrates.

The source substance Fatty acids, C8-16, 2-ethylhexyl esters contains of mainly C12 fatty acids and a branched C8 alcohol. Thus, the specification of the source substance is considered to be comparable to the target substance. This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.

The study with the source substance Fatty acids, C8-16, 2-ethylhexyl esters (CAS 135800-37-2) was conducted according to OECD 202 under GLP conditions (Wierich, 1998). Daphnia magna was used as test organism. 1 and 100 mg/L test substance were both tested as filtered test solutions. In the filtered solution of 1 mg/L, mortality or effects on the reproduction of Daphnia magna were not observed. In contrast a significant reduction of the reproduction was stated in the filtered solution of 100 mg/L. The authors supposed that the effects in the 100 mg/L filtered test solution are due to a better water soluble by-compound (for example a short chain fatty acid ester) or - less likely due to a toxic impurity. Therefore, a NOEC (21 d, reproduction) of ≥ 1 mg/L (nominal) was reported.
Thus, based on the above mentioned results, and due to the structural similarities and a similar ecotoxicological profile of the two substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no toxicological long-term effects on aquatic invertebrates are expected up to the limit of water solubility for octyl laurate.