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EC number: 224-388-8 | CAS number: 4337-75-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 4311
- Principles of method if other than guideline:
- The Critical Micellization Concentration (CMC) is determined by plotting of the graph of surface tension as a function of the logarithm of the concentration: the CMC corresponds to a singular point on this curve.
Ten solutions with different concentrations that bracket the expected critical concentration are prepared. After allowing the solutions to equilibrate at the desired test temperature, the surface tension is determined by ring method for each solution. The results are plotted as a primary curve (of surface tension as a function of concentration, which will include the region in which the CMC is located. According to the result obtained, six new solutions with closely related concentrations bracketing the CMC are prepared, either by weighing or by dilution of the stock solution. The solutions are gently agitated without stirring (taking care not to cause the formation of foam when testing strongly foaming products).The solutions are allowed to equilibrate at the required test temperature. Once 3 hours has elapsed from dissolution or dilution, whichever is the case, and until the desired temperature is attained, the surface tension of the solutions is determined. This time may be increased until the surface tension values become stable or the measurement may be commenced as soon as stability is reached. In the case of concentrations higher than the CMC the time for attaining equilibrium may be reduced to 15 minutes. Three successive measurements are carried out at 15 minute intervals at each concentration without rinsing the ring between each measurement. The pause before the measurement is adequate if the three successive measurements do not show any progressive systematic variation.
Each time the concentration is changed; the ring is rinsed with a suitable solvent (e.g. ethanol) then distilled water.
A graph of the mean surface tension vs. the logarithm of the concentrations, expressed in g.mL-1 is obtained from which the CMC is determined as;
(a) the point on the curve at which a sharp change of slope occurs, or
(b) the point on the curve at which the surface tension is considerably lower than that at higher concentrations (the abscissa of this "minimum" specifies, by definition, the range of CMC). - GLP compliance:
- no
- Type of method:
- other: Determination of critical micelle concentration
- Key result
- Water solubility:
- 0.18 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- ca. 6.3
- Details on results:
- The surface tension vs. concentration plot shows a minimum. In accordance with ISO 4311, the CMC is taken as the minimum. The standard error in the cmc is estimated from the uncertainty of the slope of the low concentration branch of the plot.
The critical micelle concentration obtained is thus 0.180 g/l. - Conclusions:
- Water solubility determined as critical micelle concentration: 0.180 g/L
- Executive summary:
The critical micelle concentration of the test item was determined from a plot of surface tension versus concentration of the test item in water in a well reported study according to national testing guideline DIN ISO 4311. The critical micelle concentration is the most appropriate parameter describing water solubility of surface active materials.
Reference
Description of key information
Surfactants like SMLT can form dispersions or emulsions in which the bioavailablity for aquatic toxicity studies is difficult to ascertain, even with careful solution preparation. Micelle formation can result in an overestimation of the bioavailable fraction even when “solutions” are apparently formed. This presents significant problems of interpretation of aquatic toxicity test results for surface active materials. Hence, the solubility of SMLT has been investigated in terms of its 'bulk' solubility in accordance with OECD 105 and the freely dissolved monomolecular form as the critical micelle concentration (CMC).
SMLT was found to have a bulk solubility in water of 444 g/L. However, the CMC for SMLT is much lower, and was determined to be 0.18 g/L.
For the CSA, the key value for water solubility of the substance is taken as the CMC i.e. 0.18 g/L.
Key value for chemical safety assessment
- Water solubility:
- 0.18 g/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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