Registration Dossier
Registration Dossier
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EC number: 223-984-5 | CAS number: 4152-09-4
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The substance is acutely harmful to fish.
Key value for chemical safety assessment
Additional information
This endpoint is not an information requirement for the tonnage band of the substance: 1 -10 tpa non-intermediate.
However, for the assessment of the substance available experimental and valid estimated data were used in a weight-of-evidence approach.
There is only one experimental result available. In a range-finding test within a bioaccumulation study by NITE (J-CHECK, 2018), a 48-h LC50 of mg/L was determined for Oryzias latipes. No further information on this result are available. It should be noted that the exposre period is too short compared to the standard exposure period of current guidelines (48 instead of 96 h).
The estimated LC50 values are in a range from > 10 to 306 mg/L. Only results from models where the substance was within the applicabilty domain of the model were used.
The following estimated LC50 values from valid QSAR models were used:
Tool |
Model |
96-h LC50 (mg/L) |
In AD |
Remarks |
VEGA v.1.1.3 |
Fish Acute (LC50) Toxicity classification (SarPy/IRFMN) 1.0.2 |
>10 to < 100 |
yes |
- |
US EPA TEST v4.2.1 |
Fathead minnow LC50 (96hr) |
125 |
yes |
Based on the mean absolute errors of the models the confidence in the predicted results is high. |
EPI Suite v4.11 |
ECOSAR v1.11: Fish |
257 |
yes |
ECOSAR class: Aliphatic amines |
QSAR Toolbox v4.3.1 |
Automated workflow for estimation of EC50/LC50 for fish |
306 |
yes |
- |
Following a worst case assessment, it can be concluded that the substance is acutely harmful to fish (LC50 > 10 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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