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Diss Factsheets
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EC number: 222-093-9 | CAS number: 3344-18-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Read across from a fairly limited reliable report of a non-standard oral feeding study using citric acid in the rat, conducted without GLP compliance, identified 5-day NOAEL values in the rat of 4000 mg/kg bw/day (which corresponds to 4680 mg tri magnesium dicitrate /kg (bw)/d*). (Hoffman, 1976; rel 2) In addition read across from a fairly limited reliable report of a non-standard 10 day feeding study using citric acid conducted without GLP compliance in mice and rats, identified 10-day NOAEL values in the mouse of 1000 and 4000 g/kg bw/day, (which corresponds to 1170 and 4680 mg tri magnesium dicitrate /kg (bw)/d*)respectively.
* based on a conversion factor of 1.17 derived by: (Mass of one mole of salt)/(mass of citric acid produced when trimagnesium dicitrate dissociates) = 451.1 / (2 * 192.9) = 1.29.
Key value for chemical safety assessment
Additional information
In accordance with Annex 11, Section 1 of REACH, the repeated dose toxicity endpoint has been waived has been waived based on the following information:
(1) The available read across repeat dose toxicity studies with citric acidin their diet reported no treatment related abnormalities.
(2) The low acute toxicity of citric acid LD50 = 5.4g/kg
(3) A long history of human exposure to citric acid and its derived salts.
In conclusion, the available read across data from citric acid, is sufficient to fulfil the information requirements for this endpoint. Information available in the public domain on tests carried out on other salts of this metal indicates that the magnesium ions are not expected to contribute to the toxicity of the substance. Additionally, the substance will dissociate when in solution, so test organisms exposure will be to the citrate and the metal ions separately.
Therefore, the hazard assessment fortri magnesium dicitrate canbe based on the properties of citric acid. All of which are sufficient to fulfil the requirements for long term repeat dose toxicity.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.