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Diss Factsheets
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EC number: 218-644-8 | CAS number: 2210-74-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The acute dermal irritation/corrosion in the rabbit was performed following the OECD Guidelines no. 404 "Acute Dermal Irritation/Corrosion" (adopted 24 April 2002) and the Method B.4 Acute Toxicity (Skin Irritation) of Commission Regulation (EC) no.440/2008.
The eye irritation in the rabbit was performed following the OECD Guidelines no. 405 "Acute Eye Irritation/Corrosion" (adopted 24 April 2002) and the Method B.5 Acute Toxicity (Eye Irritation) of Commission Regulation (EC) no.440/2008.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin Irritation test: The test item produced a primary irritation index of 2.7 and was classified as a moderate irritant to rabbit skin according to the Draize classification scheme.
No corrosive effects were noted.
Eye irritation test:
No corneal or iridial effects were noted during the study.
Minimal conjunctival irritation was noted in all treated eyes one hour after treatment and in 2 treated eyes at the 24 -hr observation.
One treated eye appeared normal at the 24-hr observation and the two other treated eyes appeared normal at the 48 -hr observation.
The test item produced a minimal irritation at 24 -hr observation. No irritation persist at 48 and 72 -hr observations.
Justification for selection of skin irritation / corrosion endpoint:
The study was performed in compliance with the principles of the Good Laboratory Practice (GLP).
Experimental data: November 2011
Justification for selection of eye irritation endpoint:
The study was performed in compliance with the principles of the Good Laboratory Practice (GLP).
Experimental data: November 2011
Effects on skin irritation/corrosion: moderately irritating
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
In the skin Irritation test, the test item produced a primary irritation index of 2.7 and was classified as a moderate irritant to rabbit skin.
In the eye irritation test, the test item produced a minimal irritation at 24 -hr observation. No irritation persist at 48 and 72 -hr observations.It does not required classification for these hazard.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.