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EC number: 217-285-4 | CAS number: 1798-60-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation: irritating to the skin (Draize Test, equivalent or similar to OECD TG 404, BASF AG, 80/204, 1981)
Eye irritation: causing severe effects in the eye (Draize test, equivalent or similar to OECD TG 405, BASF AG, 80/204, 1981)
Key value for chemical safety assessment
Additional information
Skin irritation:
In a skin irritation study conducted according to the Draize test white rabbits (4 males and 2 females) were dermal exposed to 0.5 mL of test substance for 24 hours to 6.25 cm² body surface area on intact and abraded skin, under occlusive conditions. Animals then were observed for 8 days. Irritation was scored by means of the Draize scoring system. For experiments with substance applied on intact skin following results were observed: In all animals erythema grade 3 and edema grade 1 to 3 were seen after 24 hrs. Both effects were not reversible within 8 days. Furthermore, at the end of the study (after 8 days) scale formation occurred. In this study, the test substance was a dermal irritant. The mean values of edema and erythema scores were 2.06 and 2.72.
Eye irritation:
(-)-Phenylacetylcarbinol was tested for eye irritation according to the Draize method in 6 rabbits (BASF AG, 1981, 80/204). The eyes were treated with unchanged test item without washing and were examined for reaction during a period of 8 days. The reading time points were 24, 48 and 72 hours, and day 8. Eye reaction was scored according to the Draize scoring system.
All 6 animals displayed slight to severe findings:
- Corneal opacity graded 1 affected all animals, and at test ending, corneal opacity still was evident in 5/6 cases, and reached a score of 2 in one of these 5 animals.
- Effects in the iris graded 1 concerned 4/6 animals at reading time point 24 hour; at 48 and 72 hour, 2 animals still displayed such effects, and in one of these 2 animals, the effect lasted until day 8.
- Obvious conjunctival redness graded 2 was seen in all animals at all relevant reading time points (24, 48 and 72 h); no reversibility was noticed since redness (grade 1 in 5 cases, and grade 2 in one case) still was evident in all animals at day 8.
- Chemosis almost graded 2 was seen at reading time point 24 h in all animals and lasted up to 72 h in 3 cases, with a score of 1; at day 8 no more chemosis was evident.
- Secretion above normal and graded 1 to 2 was reported for all animals and 24 hr and lasted in all animals until 72 hr. In one case, secretion above normals still was observed at day 8.
Moreover, 2 cases of myosis were reported for time point 24 h, and scarring of the eyelid was reported for 3/6 animals at 48 h, and for 5/6 animals at day 8.
All findings are indicative of severe eye irritation due to the test item. Because of corneal opacity that still was seen in 5/6 animals at test ending and because of the scarring of the eyelid that also was reported in 5/6 animals at day 8, the test item is to be designated as causing serioud damages to the eye.
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available studies are considered reliable and suitable for classification purposes under EU Directive 67/548/EEC. As a result the substance is considered to be classified R38 for skin and R41 for the eye
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under CLP Regulation 1272/2008. As a result the substance is considered to be classified in Category 2 for skin and in Category 1 for the eye.
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