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EC number: 215-628-2 | CAS number: 1335-30-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin:
Not irritating to the skin (RA calcined Kaolin)
Eye:
Causes serious eye damage
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Except for in vitro studies on the skin and eye irritating potential of silicic acid, aluminium salt, there are no in vivo data for the substance itself. Therefore a read-across approach was conducted from the structurally related substance kaolin, calcined.
Skin irritation
The skin irritation potential of silicic acid, aluminium salt was determined by Paulus (2010) according to OECD guideline (Draft proposal for a new guideline. In vitro skin irritation: human skin model test, Dezember, 2007) (Paulus, 2010, RL2). Approx. 25 mg of the test item were applied to EpiDermTM tissues. After 35 min incubation tissues were rinsed and incubated for further 42 hours. The cell viability was measured photometrically by dehydrogenase conversion of MTT into a blue formazan salt. No decrease of cell viability was detected compared to the negative control. Under these test conditions the substance has no skin irritation potential.
0.5 gram of the read across substance kaolin, calcined, as 50% (w/w) mixture in distilled water was applied to the skin of New Zealand rabbits (Engelhard Corp., 1997, RL2). The study was performed according to OECD guideline 404 under GLP-conditions. The observation period was terminated at 72 hours instead of 14 days, as no signs for dermal irritation (edema or erythema, respectively) were noted at any reading time point.
Eye irritation
The eye irritancy potential of silicic acid, aluminium salt was screened by using the Hen's Egg Test - Chorioallantoic Membrane (HET-CAM) assay (Paulus and Andres, 2010, RL1). 0.3 mL of the powdery test item was added to the membrane of 6 nine day incubated Lohmann Leghorn chicken eggs for 300 seconds. The calculated mean irritation score was in the first experiment 9.45 and in the second experiment 9.86 for the test material. As well, in a second, confirming study (Paulus and Andres, 2010, RL1)
the calculated mean irritation score for silicic acid, aluminium salt of batch no. 3080270 was 9.78. These values correspond to a classification as severely irritant. In this case, HET-CAM assay according to ICCVAM Test Method Evaluation Report: Appendix G -> ICCVAM recommended HET-CAM Method Protocol (Nov 2006) resulting in risk of serious eye damage, the substance is not to be tested in vivo.Effects on eye irritation: corrosive
Justification for classification or non-classification
Based on in vitro studies no skin irritating effects, but severe eye irritating effects are expected from the exposure to silicic acid, aluminium salt. The negative result for the skin irritating potential in vitro is supported by an in vivo study of a structurally related compound. There is no need for further testing for eye irritation in vivo.
Skin
There is conclusive data available which is not sufficient for classification.
Eye
DSD: Silicic acid, aluminium salt is classified as Xi, R41: Risk of serious eye damage.
CLP: Silicic acid, aluminium salt causes serious eye damage, Category 1, H318.
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