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Diss Factsheets
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EC number: 208-043-9 | CAS number: 506-51-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption, other
- Remarks:
- adsorption
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Please refer to the Alcohols Environmental Fate Category Report for details of the model validation, input parameters and other remarks.
- Principles of method if other than guideline:
- Method: other (calculation): various methods
- GLP compliance:
- not specified
- Type of method:
- other: Prediction
- Media:
- soil
- Radiolabelling:
- no
- Type:
- Koc
- Value:
- 1 310 000 L/kg
- Remarks on result:
- other: Calculated value
- Conclusions:
- A Koc value of 1310000 was obtained for tetracosan-1-ol using a validated calculation method.
Reference
Description of key information
Adsorption / desorption: Koc 1.31E+06 for tetracosan-1-ol based on log Kow-based QSAR validated by reliable values in the range C6-18 including hexadecan-1-ol (batch equilibrium test with sewage sludge substrate and OECD 121) and octadecan-1-ol (batch equilibrium test with sewage sludge substrate)
Key value for chemical safety assessment
- Koc at 20 °C:
- 1 310 000
Additional information
An estimated Kocvalue of 1310000 for tetracosan-1 -ol has been derived by linear regression from log Kow, based on reliable measured data within the C6 -24 aliphatic alcohols category. This is validated by available measured data from batch equilibrium and HPLC studies within the substance category. Further details are presented in the endpoint study record. The reliable estimated value of log Kow = 7.75 for tetracosan-1-ol was used as the key input to this prediction.
Van Compernolle et al. (2006) report the adsorption of several long chain aliphatic alcohols (C12, C14, C16, and C18) to wastewater treatment plant solids. In this study the sludge was sterilised with formalin to prevent biodegradation and so the results relate to adsorption in a sterile system. This is useful for the understanding of the underlying physicochemical adsorption phenomena, but it is important to recognise that the fate and behaviour of alcohols in an active biological sludge system can only be modelled successfully if the important role of rapid degradation is also taken into consideration. Alcohol sorption coefficients showed some time dependence, reaching a plateau by 72 h. The Koc value for octadecan-1-ol, the nearest chain length to the registration substance tested in this study, was 4.71E+05.
It is notable that significant technical difficulties were encountered during method development for the study of the analogous substance decan-1-ol (CAS 112-30-1) in natural standard soils, in that it was not possible to detect sufficient substance and establish equilibrium in non-sterilised soil samples, due to the rapid rate of biodegradation of the test substance by the soil microbiota.
A Koc study using HPLC (OECD 121) methodology was conducted for a range of linear aliphatic alcohols in accordance with ISO 17025 (Shell Global Solutions, 2013).The good performance of the OECD 121 method for alcohols in this category is demonstrated by the close results obtained for decan-1-ol by OECD 121 as part of the same study and by the batch equilibrium method (OECD 106), which were within a factor of 2 for the same substance.
Discussion of trends in the Category of C6-24 linear and essentially-linear aliphatic alcohols:
Substantial evidence exists within the alcohols Category, in the form of sewage sludge adsorption measurements, literature values, High Performance Liquid Chromatography (HPLC) estimates conducted in accordance with OECD Guideline 121, and a recent OECD Guideline 106 test in soils and a wastewater treatment plant sludge. Predictive methods based on log Kow and MCI have also been explored for members of this Category. The available measured data supports the following conclusions:
- The HPLC predictions correlate very well with the available measured Koc data, requiring no additional correction.
- Adsorption results in the OECD Guideline 106 study conducted with the structural analogue decan-1-ol indicate that the alcohol interacts only with the organic carbon in the soils. This confirms the expectation that setting a value of Koc is sufficient to understand adsorption to the relevant substrates (soil, sediment, sludges).
- There are no confounding factors anticipated for the alcohols in this Category (e.g. unusual interaction with the stationary phase).
- Different log Kow-based QSAR predictions of Koc vary widely depending on which equation is selected. The log Kow-based prediction derived directly from reliable measured values by HPLC and batch equilibrium tests shows a very strong correlation and low standard error.
- HPLC measured Koc values across the series show a predictable increase in Koc value as the carbon number increases. Regression analysis shows that the linear relationship between carbon number and log Koc value measured using this method is extremely well correlated with very low error.
Reference:
Sabljić A and Güsten H (1995) QSARs for soil sorption. in: overview of structure-activity relationships for environmental endpoints. Hermens JLM (ed), report prepared within the framework of the project "QSAR for prediction of fate and effects of chemicals in the environment", an international project of the Environmental Technologies RTD programme (DG XII/D-1) of the European Commission under contract number EV5V-CT92-0211.
[LogKoc: 6.12]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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